Title:
HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/058392
Kind Code:
A1
Abstract:
It is intended to provide a novel heterocyclic compound having an HCV entry inhibition
activity and a medicinal application thereof. The invention relates to the use
of the heterocyclic compound represented by the general formula [1]: [wherein
Q1 represents N= or the like, Q2 represents N or the like,
Q3 represents N= or the like, Q4 represents N or the like,
Q5 represents N or the like, R1 represents a hydrogen atom
or the like, R2 represents a hydrogen atom or the like, the ring A represents
a monocyclic aryl group which may have a substituent or the like and the ring B represents
a monocyclic aryl group which may have a substituent or the like], a pharmaceutically
acceptable salt thereof for the production of a therapeutic agent for hepatitis
C and so on.
Inventors:
UENO HIROSHI (JP)
SHIMADA TAKASHI (JP)
AOYAGI KOUICHI (JP)
KATOH SUSUMU (JP)
SHINKAI HISASHI (JP)
MOTOMURA TAKAHISA (JP)
KOMODA YASUMASA (JP)
OTSUBAKI TOMOKO (JP)
SOEJIMA YUKI (JP)
KAWAHARA IICHIRO (JP)
SHIMADA TAKASHI (JP)
AOYAGI KOUICHI (JP)
KATOH SUSUMU (JP)
SHINKAI HISASHI (JP)
MOTOMURA TAKAHISA (JP)
KOMODA YASUMASA (JP)
OTSUBAKI TOMOKO (JP)
SOEJIMA YUKI (JP)
KAWAHARA IICHIRO (JP)
Application Number:
PCT/JP2006/323637
Publication Date:
May 24, 2007
Filing Date:
November 21, 2006
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
UENO HIROSHI (JP)
SHIMADA TAKASHI (JP)
AOYAGI KOUICHI (JP)
KATOH SUSUMU (JP)
SHINKAI HISASHI (JP)
MOTOMURA TAKAHISA (JP)
KOMODA YASUMASA (JP)
OTSUBAKI TOMOKO (JP)
SOEJIMA YUKI (JP)
KAWAHARA IICHIRO (JP)
UENO HIROSHI (JP)
SHIMADA TAKASHI (JP)
AOYAGI KOUICHI (JP)
KATOH SUSUMU (JP)
SHINKAI HISASHI (JP)
MOTOMURA TAKAHISA (JP)
KOMODA YASUMASA (JP)
OTSUBAKI TOMOKO (JP)
SOEJIMA YUKI (JP)
KAWAHARA IICHIRO (JP)
International Classes:
C07D237/26; A61K31/502; A61K31/5025; A61K31/55; A61K38/21; A61K45/00; A61P1/16; A61P31/14; C07D401/14; C07D403/10; C07D403/12; C07D405/14; C07D409/04; C07D409/10; C07D409/14; C07D413/10; C07D417/10; C07D471/04; C07D487/04; C07D491/048; C07D495/04
Domestic Patent References:
| WO2002022587A1 | 2002-03-21 | |||
| WO2005099711A1 | 2005-10-27 | |||
| WO2005077915A1 | 2005-08-25 | |||
| WO2002094321A1 | 2002-11-28 | |||
| WO1999031090A1 | 1999-06-24 | |||
| WO2003082208A2 | 2003-10-09 |
Foreign References:
| US3014034A | 1961-12-19 | |||
| US3671525A | 1972-06-20 | |||
| GB889317A | 1962-02-14 |
Other References:
AMER A. ET AL.: "Dehydration of 2-(2-Arylethyl)-2-hydroxy-4-oxopentanoic Acids and Their Hydrazones to Form Heterocycles", JOURNAL FUER PRAKTISCHE CHEMIE CHEMIKER-ZEITUNG, vol. 339, no. 1, 1997, pages 20 - 25, XP008048483
EL-ASHRY E.H. ET AL.: "Access to the 2,3-Dihydropyridazin-3-one and as-Triazino[3,4-a]phthalazine Ring Systems from 4-Aryl-2-oxo-butanoic Acids", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 24, no. 1, 1987, pages 63 - 68, XP002331601
NITTA Y. ET AL.: "Pyridazin-derivate. V. Synthese der Derivate des 6-Phenyl-3(2H)-pyridazinons", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 12, no. 1, 1964, pages 69 - 73, XP003013318
TANAKA C. ET AL.: "New Pharmacology, Kaitei Dai 3 Han", 1 August 1997, pages: 454, XP003013319
VAN DER MEY M. ET AL.: "Novel Selective PDE4 Inhibitors. 1. Synthesis, Structure-Activity Relationships, and Molecular Modeling of 4-(3,4-Dimethoxyphenyl)-2H-phthalazin-1-ones and Analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 16, 2 August 2001 (2001-08-02), pages 2511 - 2522, XP002222830
PIAZ V.D. ET AL.: "Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as Peripheral Vasodilator Agents", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 44, no. 17, August 2002 (2002-08-01), pages 227 - 233, XP003013320
TSUBOTA A.: "Virus-sei Kan'en no Genjo to Tenbo", 25 July 2003, article "Separate Volume Igaku no Ayumi", pages: 87 - 90, XP003013321
EL-ASHRY E.H. ET AL.: "Access to the 2,3-Dihydropyridazin-3-one and as-Triazino[3,4-a]phthalazine Ring Systems from 4-Aryl-2-oxo-butanoic Acids", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 24, no. 1, 1987, pages 63 - 68, XP002331601
NITTA Y. ET AL.: "Pyridazin-derivate. V. Synthese der Derivate des 6-Phenyl-3(2H)-pyridazinons", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 12, no. 1, 1964, pages 69 - 73, XP003013318
TANAKA C. ET AL.: "New Pharmacology, Kaitei Dai 3 Han", 1 August 1997, pages: 454, XP003013319
VAN DER MEY M. ET AL.: "Novel Selective PDE4 Inhibitors. 1. Synthesis, Structure-Activity Relationships, and Molecular Modeling of 4-(3,4-Dimethoxyphenyl)-2H-phthalazin-1-ones and Analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 16, 2 August 2001 (2001-08-02), pages 2511 - 2522, XP002222830
PIAZ V.D. ET AL.: "Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as Peripheral Vasodilator Agents", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 44, no. 17, August 2002 (2002-08-01), pages 227 - 233, XP003013320
TSUBOTA A.: "Virus-sei Kan'en no Genjo to Tenbo", 25 July 2003, article "Separate Volume Igaku no Ayumi", pages: 87 - 90, XP003013321
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka 44, JP)
Download PDF: