Title:
HETEROCYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/025358
Kind Code:
A1
Abstract:
Disclosed is a heterocyclic compound having a strong Raf inhibitory activity.
Specifically disclosed is a compound represented by the formula (I), (II) or
(III) below, or a salt thereof. (In the formulae, the symbols are as defined in
the description.)
Inventors:
HIROSE MASAAKI (JP)
OKANIWA MASANORI (JP)
IMADA TAKASHI (JP)
OKANIWA MASANORI (JP)
IMADA TAKASHI (JP)
Application Number:
PCT/JP2008/065011
Publication Date:
February 26, 2009
Filing Date:
August 22, 2008
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
HIROSE MASAAKI (JP)
OKANIWA MASANORI (JP)
IMADA TAKASHI (JP)
HIROSE MASAAKI (JP)
OKANIWA MASANORI (JP)
IMADA TAKASHI (JP)
International Classes:
C07D235/30; A61K31/423; A61K31/428; A61K31/496; A61P35/00; A61P43/00; C07D263/58; C07D277/82; C07D417/12
Domestic Patent References:
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| WO2005037273A1 | 2005-04-28 | |||
| WO2003074515A1 | 2003-09-12 | |||
| WO2007121484A2 | 2007-10-25 | |||
| WO2000042012A1 | 2000-07-20 | |||
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Foreign References:
| US2399026A | 1946-04-23 |
Other References:
HASEGAWA M. ET AL: "Discovery of novel benzimidazoles as potent inhibitors of TIE2 and VEGFR-2 tyrosine kinase receptors", J. MED. CHEM., vol. 50, no. 18, 8 April 2007 (2007-04-08), pages 4453 - 4470, XP002513776
See also references of EP 2181987A4
CURRENT PHARMACEUTICAL DESIGN, vol. 8, 2000, pages 2269 - 2278
HIGH PERFORMANCE POLYMERS, vol. 8, no. 2, 1996, pages 307 - 314
INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 30B, no. 5, 1991, pages 494 - 8
YAKUGAKU ZASSHI, vol. 78, 1958, pages 482 - 5
INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 32B, no. 10, 1993, pages 1035 - 44
ZEITSCHRIFT FUER NATURFORSCHUNG, C: JOURNAL OF BIOSCIENCES, vol. 45, no. 11-12, 1990, pages 1210 - 14
INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 29B, no. 5, 1990, pages 464 - 70
J. AM. CHEM. SOC., vol. 116, 1994, pages 5969 - 5970
J. AM. CHEM. SOC., vol. 116, 1994, pages 7901 - 7902
PURE APPL. CHEM., vol. 71, no. 8, 1999, pages 1417 - 1423
SKEHAN ET AL., JOURNAL OF NATIONAL CANCER INSTITUTE, vol. 82, 1990, pages 1107 - 1112
See also references of EP 2181987A4
CURRENT PHARMACEUTICAL DESIGN, vol. 8, 2000, pages 2269 - 2278
HIGH PERFORMANCE POLYMERS, vol. 8, no. 2, 1996, pages 307 - 314
INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 30B, no. 5, 1991, pages 494 - 8
YAKUGAKU ZASSHI, vol. 78, 1958, pages 482 - 5
INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 32B, no. 10, 1993, pages 1035 - 44
ZEITSCHRIFT FUER NATURFORSCHUNG, C: JOURNAL OF BIOSCIENCES, vol. 45, no. 11-12, 1990, pages 1210 - 14
INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 29B, no. 5, 1990, pages 464 - 70
J. AM. CHEM. SOC., vol. 116, 1994, pages 5969 - 5970
J. AM. CHEM. SOC., vol. 116, 1994, pages 7901 - 7902
PURE APPL. CHEM., vol. 71, no. 8, 1999, pages 1417 - 1423
SKEHAN ET AL., JOURNAL OF NATIONAL CANCER INSTITUTE, vol. 82, 1990, pages 1107 - 1112
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-ku,Osaka-sh, Osaka 44, JP)
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