Title:
HETEROCYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/118845
Kind Code:
A1
Abstract:
Provided is a compound having AMPA receptor function-enhancing activity that is useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease, attention deficit hyperactivity disorder (ADHD), and the like. The compound represented by formula (I) [where each of the symbols in the formula are as defined in the Specification], or a salt thereof, has AMPA receptor function-enhancing activity and is useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease, attention deficient hyperactivity disorder (ADHD), and the like.
Inventors:
TOYOFUKU MASASHI (JP)
NAKAMURA SHINJI (JP)
HONDA EIJI (JP)
NAKAMURA SHINJI (JP)
HONDA EIJI (JP)
Application Number:
PCT/JP2013/052950
Publication Date:
August 15, 2013
Filing Date:
February 07, 2013
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
International Classes:
C07D513/18; A61K31/549; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C07D513/04
Domestic Patent References:
| WO2010075204A2 | 2010-07-01 | |||
| WO2010056722A1 | 2010-05-20 | |||
| WO2012020848A1 | 2012-02-16 | |||
| WO2009011851A1 | 2009-01-22 |
Foreign References:
| JP2006188506A | 2006-07-20 | |||
| JP2005002113A | 2005-01-06 | |||
| JP2010508328A | 2010-03-18 | |||
| JP2010526808A | 2010-08-05 | |||
| JP2011503002A | 2011-01-27 | |||
| JPH0437742A | 1992-02-07 |
Other References:
DESOS, P. ET AL.: "Enantioselective synthesis of a pyrrolobenzothiadiazine derivative S 18986, a new AMPA receptor positive modulator", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 24, 17 December 1996 (1996-12-17), pages 3003 - 3008, XP004135943
PHARMACOLOGICAL REVIEWS, vol. 51, 1999, pages 7 - 61
NEUROPHARMACOLOGY, vol. 34, 1995, pages 123 - 139
ANN. REV. NEUROSCI., vol. 25, 2002, pages 103 - 126
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, vol. 7, 2008, pages 129 - 143
CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, 2006, pages 571 - 579
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY, 1993, pages 27 - 29
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS INC.
"Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, WILEY-VCH
"ShinJikken Kagaku Kouza", CHEMICAL SOCIETY OF JAPAN
"Greene's PROTECTIVE GROUPS in ORGANIC SYNTHESIS", 2006, WILEY-INTERSCIENCE
"ShinJikken Kagaku Koza", THE CHEMICAL SOCIETY OF JAPAN
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS
"ShinJikken Kagaku Koza", CHEMICAL SOCIETY OF JAPAN
SYNTHETIC COMMUNICATIONS, vol. 14, 1984, pages 401 - 406
TETRAHEDRON, vol. 3, 1958, pages 175
JOURNAL OF ORGANIC CHEMISTRY, vol. 20, 1955, pages 1702 - 1707
JOURNAL OF ORGANIC CHEMISTRY, vol. 56, 1991, pages 3549 - 3556
"Molecule Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
See also references of EP 2813508A4
PHARMACOLOGICAL REVIEWS, vol. 51, 1999, pages 7 - 61
NEUROPHARMACOLOGY, vol. 34, 1995, pages 123 - 139
ANN. REV. NEUROSCI., vol. 25, 2002, pages 103 - 126
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, vol. 7, 2008, pages 129 - 143
CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, vol. 9, 2006, pages 571 - 579
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY, 1993, pages 27 - 29
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS INC.
"Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, WILEY-VCH
"ShinJikken Kagaku Kouza", CHEMICAL SOCIETY OF JAPAN
"Greene's PROTECTIVE GROUPS in ORGANIC SYNTHESIS", 2006, WILEY-INTERSCIENCE
"ShinJikken Kagaku Koza", THE CHEMICAL SOCIETY OF JAPAN
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS
"ShinJikken Kagaku Koza", CHEMICAL SOCIETY OF JAPAN
SYNTHETIC COMMUNICATIONS, vol. 14, 1984, pages 401 - 406
TETRAHEDRON, vol. 3, 1958, pages 175
JOURNAL OF ORGANIC CHEMISTRY, vol. 20, 1955, pages 1702 - 1707
JOURNAL OF ORGANIC CHEMISTRY, vol. 56, 1991, pages 3549 - 3556
"Molecule Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
See also references of EP 2813508A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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