Title:
HETEROCYCLIC COMPOUND USED AS FGFR INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2018/010514
Kind Code:
A1
Abstract:
The present invention relates to a heterocyclic compound, a pharmaceutical composition containing the heterocyclic compound, a preparation method therefor, and use thereof as a fibroblast growth factor receptor (FGFR) inhibitor. The compound is a heterocyclic compound as shown in formula I, or a pharmaceutically acceptable salt thereof, prodrug, solvent compound, polymorph, isomer and a stable isotopic derivative. The present invention also relates to use of the compound for the treatment or prevention of related diseases which are FGFR-mediated such as cancer and a method for applying the compound to treat said diseases.
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Inventors:
KONG XIANGLONG NORMAN (CN)
ZHOU CHAO (CN)
ZHENG ZHIXIANG (CN)
ZHOU CHAO (CN)
ZHENG ZHIXIANG (CN)
Application Number:
PCT/CN2017/088038
Publication Date:
January 18, 2018
Filing Date:
June 13, 2017
Export Citation:
Assignee:
NANJING INNOCARE PHARMA TECH CO LTD (CN)
International Classes:
C07D213/84; A61K31/444; A61K31/4545; A61K31/496; A61K31/506; A61K31/5377; A61P35/00; C07D401/12; C07D401/14; C07D413/14
Domestic Patent References:
| WO2007059341A2 | 2007-05-24 | |||
| WO2013024427A1 | 2013-02-21 | |||
| WO2006009741A1 | 2006-01-26 |
Foreign References:
| CN1678311A | 2005-10-05 | |||
| CN101553473A | 2009-10-07 | |||
| CN101304998A | 2008-11-12 | |||
| CN1508130A | 2004-06-30 | |||
| CN102471280A | 2012-05-23 |
Other References:
GAOQUAN LI ET AL.: "Synthesis and biological evaluation of 1-(2, 4, 5-trisubsti-tuted phenyl)-3-(5-cyanopyrazin-2-yl) ureas as potent Chk 1 kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 8, 30 January 2006 (2006-01-30), pages 2293 - 2298, XP027966327
NAGAMATSU, K. ET AL.: "Reactions of 2-Triphenylphosphoimino-L-Azaazulenes with Aryl Isocyanates and Aryl Isothiocyanates", HETEROCYCLES, vol. 67, no. 1, 31 December 2006 (2006-12-31), pages 337 - 351, XP055457126
CLAYDEN, J. ET AL.: "N, N'-Diarylureas: ANew Family of Atropisomers Exhibiting Highly Diastereoselective Reactivity", J. ORG. CHEM., vol. 73, no. 12, 10 April 2008 (2008-04-10), pages 4415 - 4423, XP055457130
KIM, K.H. ET AL.: "Conformational Switching on Platinum (II) Coordination Plane Triggered by Oxalate Anion", BULL. KOREAN CHEM. SOC., vol. 32, no. 9, 31 December 2011 (2011-12-31), pages 3497 - 3450, XP055457132
LU , T.W. ET AL.: "Molecular Switch Based on Very Weak Association between BPX26C6 and Two Recognition Units", ORGANIC LETTERS, vol. 15, no. 22, 30 October 2013 (2013-10-30), pages 5742 - 5745, XP055457134
YANG, ZHAO ET AL.: "Identification of inhibitors for vascular endothelial growth factor receptor by using dynamic combinatorial chemistry", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 7, 22 January 2016 (2016-01-22), pages 1671 - 1674, XP029453962
AN, YING ET AL.: "Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 13, 7 May 2016 (2016-05-07), pages 3067 - 3072, XP029568927
See also references of EP 3489223A4
NAGAMATSU, K. ET AL.: "Reactions of 2-Triphenylphosphoimino-L-Azaazulenes with Aryl Isocyanates and Aryl Isothiocyanates", HETEROCYCLES, vol. 67, no. 1, 31 December 2006 (2006-12-31), pages 337 - 351, XP055457126
CLAYDEN, J. ET AL.: "N, N'-Diarylureas: ANew Family of Atropisomers Exhibiting Highly Diastereoselective Reactivity", J. ORG. CHEM., vol. 73, no. 12, 10 April 2008 (2008-04-10), pages 4415 - 4423, XP055457130
KIM, K.H. ET AL.: "Conformational Switching on Platinum (II) Coordination Plane Triggered by Oxalate Anion", BULL. KOREAN CHEM. SOC., vol. 32, no. 9, 31 December 2011 (2011-12-31), pages 3497 - 3450, XP055457132
LU , T.W. ET AL.: "Molecular Switch Based on Very Weak Association between BPX26C6 and Two Recognition Units", ORGANIC LETTERS, vol. 15, no. 22, 30 October 2013 (2013-10-30), pages 5742 - 5745, XP055457134
YANG, ZHAO ET AL.: "Identification of inhibitors for vascular endothelial growth factor receptor by using dynamic combinatorial chemistry", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 7, 22 January 2016 (2016-01-22), pages 1671 - 1674, XP029453962
AN, YING ET AL.: "Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 13, 7 May 2016 (2016-05-07), pages 3067 - 3072, XP029568927
See also references of EP 3489223A4
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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