HETEROCYCLIC COMPOUND - TAKEDA PHARMACEUTICAL

Title:

HETEROCYCLIC COMPOUND

Document Type and Number:

WIPO Patent Application WO/2009/051244

Kind Code:

A1

Abstract:

Disclosed is a compound represented by the following formula (I). (In the formula, the symbols are as defined in the description.) This compound has an excellent RBP4 lowering effect, and is useful as an agent for prevention or treatment of diseases or conditions associated with increase of RBP4.

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Inventors:

KASAI SHIZUO (JP)
KAKU TOMOHIRO (JP)
KAMAURA MASAHIRO (JP)

Application Number:

PCT/JP2008/068901

Publication Date:

April 23, 2009

Filing Date:

October 17, 2008

Export Citation:

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Assignee:

TAKEDA PHARMACEUTICAL (JP)
KASAI SHIZUO (JP)
KAKU TOMOHIRO (JP)
KAMAURA MASAHIRO (JP)

International Classes:

C07D205/04; A61K31/397; A61K31/40; A61K31/41; A61K31/4188; A61K31/4196; A61K31/422; A61K31/427; A61K31/437; A61K31/4427; A61K31/445; A61K31/4523; A61K31/454; A61K31/4545; A61K31/4985; A61K31/506; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/04; A61P9/12; A61P13/12; A61P19/10; A61P21/00; A61P25/00; A61P27/12; A61P29/00; A61P31/00; C07D207/08; C07D211/44; C07D401/06; C07D403/12; C07D413/06; C07D413/12; C07D417/06; C07D471/04; C07D495/04; C07D513/04

Domestic Patent References:

WO2007092435A2	2007-08-16
WO2006023778A2	2006-03-02
WO2005059564A1	2005-06-30
WO2006023778A2	2006-03-02
WO2002055501A2	2002-07-18
WO2001014372A2	2001-03-01
WO1997010224A1	1997-03-20
WO2001082925A1	2001-11-08
WO2001087834A1	2001-11-22

Foreign References:

US5130309A	1992-07-14
JPS5331669A	1978-03-25

Other References:

See also references of EP 2202223A4
NATURE, vol. 436, 2005, pages 356 - 362
CELL METAB., vol. 6, 2007, pages 79 - 87
N. ENGL. J. MED., vol. 354, 2006, pages 2552 - 2563
BIOCHIM. BIOPHYS. ACTA, vol. 1294, 1996, pages 48 - 54
J. ATHEROSCLER. THROMB., vol. 13, 2006, pages 209 - 215
N. ENGL. J. MED., vol. 355, 2006, pages 1392 - 1395
DIABETES, vol. 56, no. 1, 2007, pages A378
TETRAHEDRON LETTERS, vol. 34, 1993, pages 1639
TETRAHEDRON LETTERS, vol. 35, 1994, pages 5081
TETRAHEDRON LETTERS, vol. 36, 1995, pages 2531
TETRAHEDRON LETTERS, vol. 37, 1996, pages 2549
THE JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, 2001, pages 2933

Attorney, Agent or Firm:

TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome,Chuo-ku, Osaka-shi, Osaka 44, JP)

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