Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2013/018695
Kind Code:
A1
Abstract:
To provide a heterocyclic compound which has an RORγt inhibitory effect. A compound represented by formula (I) or a salt thereof. (In the formula, ring A represents an optionally substituted cyclic group; Q represents a bonding hand or the like; R1 represents a substituent; ring B represents a thiazole ring, an isothiazole ring or a dihydrothiazole ring, each of which can be additionally substituted by a substituent other than R2; and R2 represents an optionally substituted aminocarbonyl-C1-6 alkyl group or the like.)
Inventors:
YAMAMOTO SATOSHI (JP)
SHIRAI JUNYA (JP)
OCHIDA ATSUKO (JP)
FUKASE YOSHIYUKI (JP)
TOMATA YOSHIHIDE (JP)
SATO AYUMU (JP)
MIURA SHOTARO (JP)
YONEMORI KAZUKO (JP)
KOYAMA RYOKICHI (JP)
SHIRAI JUNYA (JP)
OCHIDA ATSUKO (JP)
FUKASE YOSHIYUKI (JP)
TOMATA YOSHIHIDE (JP)
SATO AYUMU (JP)
MIURA SHOTARO (JP)
YONEMORI KAZUKO (JP)
KOYAMA RYOKICHI (JP)
Application Number:
PCT/JP2012/069138
Publication Date:
February 07, 2013
Filing Date:
July 27, 2012
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
YAMAMOTO SATOSHI (JP)
SHIRAI JUNYA (JP)
OCHIDA ATSUKO (JP)
FUKASE YOSHIYUKI (JP)
TOMATA YOSHIHIDE (JP)
SATO AYUMU (JP)
MIURA SHOTARO (JP)
YONEMORI KAZUKO (JP)
KOYAMA RYOKICHI (JP)
YAMAMOTO SATOSHI (JP)
SHIRAI JUNYA (JP)
OCHIDA ATSUKO (JP)
FUKASE YOSHIYUKI (JP)
TOMATA YOSHIHIDE (JP)
SATO AYUMU (JP)
MIURA SHOTARO (JP)
YONEMORI KAZUKO (JP)
KOYAMA RYOKICHI (JP)
International Classes:
C07D417/04; A61K31/427; A61K31/438; A61K31/4439; A61K31/454; A61K31/4725; A61K31/496; A61K31/497; A61K31/5377; A61K31/541; A61K31/551; A61K31/553; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/16; A61P7/00; A61P7/06; A61P9/00; A61P11/00; A61P11/06; A61P13/10; A61P13/12; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P37/00; A61P37/06; A61P43/00; C07D417/14; C07D491/107
Domestic Patent References:
| WO2006116355A1 | 2006-11-02 | |||
| WO2010049144A2 | 2010-05-06 | |||
| WO2012101263A1 | 2012-08-02 | |||
| WO2012101261A1 | 2012-08-02 | |||
| WO2010142752A1 | 2010-12-16 |
Other References:
KHILYA,V.P. ET AL.: "Chemistry of heteroanalogs of isoflavones. 9. Reaction of thiazole analogs of isoflavones with nucleophilic and electrophilic reagents", KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, no. 3, 1982, pages 321 - 7, XP055141915
KHILYA,V.P. ET AL.: "Synthesis and hypolipidemic activity of3-(4-thiazolyl)-6-alkyl-7-alkoxychromones", KHIMIKO-FARMATSEVTICHESKII ZHURNAL, vol. 15, no. 11, 1981, pages 40 - 5, XP008172315
CELL, vol. 126, 2006, pages 1121 - 1133
NAT. IMMUNOL., vol. 9, 2008, pages 641 - 649
NATURE, vol. 472, 2011, pages 491
MOL. PHARMACOL., vol. 77, no. 2, 2010, pages 228
NATURE, vol. 472, 2011, pages 486
ACS CHEM. BIOL., vol. 5, no. 11, 2010, pages 1029
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, 2011, pages 22707
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, 2010, pages 5013
BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1801, 2010, pages 917
MOL. ENDOCRINOL, vol. 24, no. 5, May 2010 (2010-05-01), pages 923
"Jikken Kagaku Kouza 22, organic synthesis IV", 1991, THE CHEMICAL SOCIETY OF JAPAN
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTION 1: ORGANIC AND BIOORGANIC CHEMISTRY, vol. 6, 1981, pages 1754 - 1762
"Jikken Kagaku Kouza 24, organic synthesis VI", 1991, THE CHEMICAL SOCIETY OF JAPAN
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
"Molecule Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
JOURNAL OF ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
CHEMICAL AND PHARMACEUTICAL BULLETIN (CHEM. PHARM. BULL, vol. 38, 1990, pages 2792 - 2796
KHILYA,V.P. ET AL.: "Synthesis and hypolipidemic activity of3-(4-thiazolyl)-6-alkyl-7-alkoxychromones", KHIMIKO-FARMATSEVTICHESKII ZHURNAL, vol. 15, no. 11, 1981, pages 40 - 5, XP008172315
CELL, vol. 126, 2006, pages 1121 - 1133
NAT. IMMUNOL., vol. 9, 2008, pages 641 - 649
NATURE, vol. 472, 2011, pages 491
MOL. PHARMACOL., vol. 77, no. 2, 2010, pages 228
NATURE, vol. 472, 2011, pages 486
ACS CHEM. BIOL., vol. 5, no. 11, 2010, pages 1029
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, 2011, pages 22707
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, 2010, pages 5013
BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1801, 2010, pages 917
MOL. ENDOCRINOL, vol. 24, no. 5, May 2010 (2010-05-01), pages 923
"Jikken Kagaku Kouza 22, organic synthesis IV", 1991, THE CHEMICAL SOCIETY OF JAPAN
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTION 1: ORGANIC AND BIOORGANIC CHEMISTRY, vol. 6, 1981, pages 1754 - 1762
"Jikken Kagaku Kouza 24, organic synthesis VI", 1991, THE CHEMICAL SOCIETY OF JAPAN
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
"Molecule Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
JOURNAL OF ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
CHEMICAL AND PHARMACEUTICAL BULLETIN (CHEM. PHARM. BULL, vol. 38, 1990, pages 2792 - 2796
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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