Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/157569
Kind Code:
A1
Abstract:
Provided is a compound having an excellent JAK-inhibiting effect, the compound being is useful as an agent for the prevention or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, and the like) and cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, and the like) or a salt thereof. The invention relates to a compound represented by formula (I) [in the formula, each symbol is as defined in the specification] or a salt thereof.
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Inventors:
YOSHIDA MASATO (JP)
NAGAMIYA HIROYUKI (JP)
OHBA YUSUKE (JP)
SETO MASAKI (JP)
YOGO TAKATOSHI (JP)
SASAKI SATOSHI (JP)
TOKUNAGA NORIHITO (JP)
ASO KAZUYOSHI (JP)
NAGAMIYA HIROYUKI (JP)
OHBA YUSUKE (JP)
SETO MASAKI (JP)
YOGO TAKATOSHI (JP)
SASAKI SATOSHI (JP)
TOKUNAGA NORIHITO (JP)
ASO KAZUYOSHI (JP)
Application Number:
PCT/JP2014/058999
Publication Date:
October 02, 2014
Filing Date:
March 27, 2014
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
International Classes:
C07D471/04; A61K31/437; A61K31/438; A61K31/4545; A61K31/496; A61K31/4985; A61K31/5377; A61K31/541; A61K31/553; A61P1/04; A61P17/00; A61P17/06; A61P19/08; A61P25/00; A61P29/00; A61P37/02; A61P37/06; A61P43/00; C07D519/00
Domestic Patent References:
| WO2012066061A1 | 2012-05-24 | |||
| WO2011130146A1 | 2011-10-20 | |||
| WO2013125543A1 | 2013-08-29 | |||
| WO2013180265A1 | 2013-12-05 | |||
| WO2012030922A1 | 2012-03-08 | |||
| WO2010142752A1 | 2010-12-16 |
Foreign References:
| JP2012507569A | 2012-03-29 |
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"Nature Immunology", vol. 1246, 2011, ACADEMY OF SCIENCE, pages: 34 - 40
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 127, no. 3, 2011, pages 701 - 721
CYTOKINE & GROWTH FACTOR REVIEWS, vol. 19, 2008, pages 41 - 52
INVEST OPHTHALMOL VIS SCI., vol. 49, no. 7, July 2008 (2008-07-01), pages 3058 - 3064
ANN RHEUM DIS., vol. 69, no. 7, July 2010 (2010-07-01), pages 1325 - 1328
CLINICAL SCIENCE, vol. 122, 2012, pages 143 - 159
TRENDS BIOCHEM. SCI., vol. 33, 2008, pages 122 - 131
J EXP MED, vol. 205, 2008, pages 751 - 758
ONCOGENE, vol. 25, 2006, pages 4016 - 4026
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 363, 2010, pages 1117 - 1127
J IMMUNOL., vol. 184, no. 9, 1 May 2010 (2010-05-01), pages 4605 - 9
NAT MED., vol. 18, no. 12, December 2012 (2012-12-01), pages 1812 - 9
FRONT BIOSCI., vol. 17, 1 June 2011 (2011-06-01), pages 3214 - 32
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY, 1997, pages 3285 - 3290
CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 32, no. 9, 1984, pages 3384 - 95
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999, 1978, pages 857 - 62
PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 170, 2001, pages 171 - 179
CHEMICAL REVIEWS, vol. 95, 1995, pages 2457
SYNTHESIS, vol. 1, 1981, pages 1 - 28
SYNTHETIC COMMUNICATIONS, vol. 38, no. 5, 2008, pages 674 - 683
JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 2, 2012, pages 797 - 811
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
JOURNAL OF ANTIBIOTICS (J. ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
CHEM. PHARM. BULL, vol. 38, 1990, pages 2792 - 2796
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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