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Patent Searching and Data


Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/069173
Kind Code:
A1
Abstract:
Provided is a compound that has cholinergic muscarinic M1 receptor positive allosteric modulator activity and is useful as a medicine, e.g., a preventative or treatment agent for Alzheimer's disease, schizophrenia, pain, sleep disorders, Parkinson's disease with cognitive impairment, or dementia with Lewy bodies, etc. The present invention relates to a compound indicated by formula (I) or a salt thereof. Each symbol in the formula (I) is as described in the Description.

Inventors:
SUGIMOTO TAKAHIRO (JP)
SUZUKI SHINKICHI (JP)
SAKAMOTO HIROKI (JP)
YAMADA MASAMI (JP)
NAKAMURA MINORU (JP)
KAMATA MAKOTO (JP)
SHIMOKAWA KENICHIRO (JP)
OGINO MASAKI (JP)
KIMURA EIJI (JP)
MURAKAMI MASATAKA (JP)
KOJIMA TAKUTO (JP)
YONEMORI JINICHI (JP)
Application Number:
PCT/JP2016/081016
Publication Date:
April 27, 2017
Filing Date:
October 19, 2016
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D239/88; A61K31/517; A61K31/53; A61P25/04; A61P25/16; A61P25/18; A61P25/20; A61P25/28; A61P43/00; C07D401/06; C07D401/14; C07D403/06; C07D403/10; C07D405/14
Domestic Patent References:
WO2010059773A12010-05-27
WO2011025851A12011-03-03
WO2011084371A12011-07-14
WO2011075371A12011-06-23
WO2012003147A12012-01-05
WO2010096338A12010-08-26
WO2010123716A12010-10-28
WO2011049731A12011-04-28
Foreign References:
JP2009504626A2009-02-05
JP2008531533A2008-08-14
JP2003508353A2003-03-04
JPH06509576A1994-10-27
JP2012527434A2012-11-08
Other References:
KUDUK, S. D. ET AL.: "Novel M1 allosteric ligands: a patent review", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 22, no. 12, 2012, pages 1385 - 1398, XP055304912
ABDUL-RIDHA, A. ET AL.: "Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor", J. BIOL. CHEM., vol. 289, no. 48, 2014, pages 33701 - 33711, XP055377423
MISTRY, S. N. ET AL.: "Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor", ACS CHEMICAL NEUROSCIENCE, vol. 7, no. 5, 2016, pages 647 - 661, XP055377426
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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