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Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/066545
Kind Code:
A1
Abstract:
Provided is a drug that can decompose a target intracellular protein specifically and is effective for the prevention or treatment of diseases associated with the target protein. An SNIPER compound produced by linking a specific IAP ligand, through a linker, to a ligand capable of specifically binding to a target intracellular protein.

Inventors:
NAITO Mikihiko (3-25-26 tonomachi, kawasaki-ku, kawasaki-sh, Kanagawa 21, 〒2100821, JP)
OHOKA Nobumichi (3-25-26 tonomachi, kawasaki-ku, kawasaki-sh, Kanagawa 21, 〒2100821, JP)
SHIBATA Norihito (3-25-26 tonomachi, kawasaki-ku, kawasaki-sh, Kanagawa 21, 〒2100821, JP)
OKUHIRA Keiichiro (2-24 Shinkura-cho, Tokushima-sh, Tokushima 01, 〒7708501, JP)
CHO Nobuo (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
NAGAI Katsunori (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
ITO Masahiro (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
MIYAMOTO Naoki (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
MORITA Yoko (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
NARA Hiroshi (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
FUJIMORI Ikuo (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
UJIKAWA Osamu (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
HOMMA Misaki (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
MAEZAKI Hironobu (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
MORISHITA Nao (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
SHIMOKAWA Kenichiro (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
Application Number:
JP2017/035934
Publication Date:
April 12, 2018
Filing Date:
October 03, 2017
Export Citation:
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Assignee:
JAPAN HEALTH SCIENCES FOUNDATION (11-1, Iwamoto-cho 2-chome Chiyoda-k, Tokyo 32, 〒1010032, JP)
International Classes:
C07K5/062; A61K38/05; A61P35/00; C12N15/09
Domestic Patent References:
WO2008016893A12008-02-07
WO2005097791A12005-10-20
Foreign References:
JP2013056837A2013-03-28
Other References:
OKUHIRA, K. ET AL.: "Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.", CANCER SCIENCE, vol. 104, no. 11, November 2013 (2013-11-01), pages 1492 - 1498, XP055501418
OKUHIRA, K. ET AL.: "Specific degradation of CRABP- II via cIAPl-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.", FEBS LETTERS, vol. 585, no. 8, 8 March 2011 (2011-03-08), pages 1147 - 1152, XP028194456
ITOH, Y. ET AL.: "Design, synthesis and biological evaluation of nuclear receptor-degradation inducers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 22, 15 November 2011 (2011-11-15), pages 6768 - 6778, XP028328576
ITOH, Y. ET AL.: "Development of target protein-selective degradation inducer for protein knockdown.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 10, 15 May 2011 (2011-05-15), pages 3229 - 3241, XP028384646
SHIBATA, N. ET AL.: "Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands", CANCER SCIENCE, vol. 108, no. 8, August 2017 (2017-08-01), pages 1657 - 1666, XP055501430
SHIBATA, N. ET AL.: "Development of protein degradation inducers of androgen receptor by conjugation of androgen receptor ligands and inhibitor of apoptosis protein ligands.", JOURNAL OF MEDICINAL CHEMISTRY, 23 June 2017 (2017-06-23), XP055501434
Attorney, Agent or Firm:
MAEDA & PARTNERS (Shin-Daibiru Bldg. 23F, 2-1 Dojimahama 1-chome, Kita-ku, Osaka-sh, Osaka 04, 〒5300004, JP)
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