Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/235838
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound that can be useful for prevention of, or therapy for, constipation and the like. The present invention provides: a compound represented by formula (I) (refer to the description for the meanings of the symbols in the formula); or a salt thereof.
Inventors:
TAKAMI KAZUAKI (JP)
SETO MASAKI (JP)
SASAKI SHINOBU (JP)
ANDO HARUHI (JP)
OGINO MASAKI (JP)
OHASHI TOMOKO (JP)
IMAEDA TOSHIHIRO (JP)
FUJIMORI IKUO (JP)
TSUKIMI YASUHIRO (JP)
YAMADA MASAMI (JP)
SHIMOKAWA KENICHIRO (JP)
WAKABAYASHI TAKESHI (JP)
MURAKAMI MASATAKA (JP)
FUSHIMI MAKOTO (US)
OKAWA TOMOHIRO (JP)
YONEMORI JINICHI (JP)
OHASHI TOMOHIRO (JP)
SUZUKI HIDEO (JP)
MAEZAKI HIRONOBU (JP)
SATO AYUMU (JP)
ASANO YASUTOMI (JP)
SWANN STEVE (US)
SETO MASAKI (JP)
SASAKI SHINOBU (JP)
ANDO HARUHI (JP)
OGINO MASAKI (JP)
OHASHI TOMOKO (JP)
IMAEDA TOSHIHIRO (JP)
FUJIMORI IKUO (JP)
TSUKIMI YASUHIRO (JP)
YAMADA MASAMI (JP)
SHIMOKAWA KENICHIRO (JP)
WAKABAYASHI TAKESHI (JP)
MURAKAMI MASATAKA (JP)
FUSHIMI MAKOTO (US)
OKAWA TOMOHIRO (JP)
YONEMORI JINICHI (JP)
OHASHI TOMOHIRO (JP)
SUZUKI HIDEO (JP)
MAEZAKI HIRONOBU (JP)
SATO AYUMU (JP)
ASANO YASUTOMI (JP)
SWANN STEVE (US)
Application Number:
PCT/JP2018/023357
Publication Date:
December 27, 2018
Filing Date:
June 19, 2018
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D491/048; A61K31/4355; A61K31/444; A61K31/501; A61K31/506; A61P1/10
Domestic Patent References:
| WO2013129622A1 | 2013-09-06 | |||
| WO2016009297A1 | 2016-01-21 | |||
| WO2018042362A1 | 2018-03-08 | |||
| WO2017143041A1 | 2017-08-24 | |||
| WO2013129622A1 | 2013-09-06 | |||
| WO2014077401A1 | 2014-05-22 | |||
| WO2015174534A1 | 2015-11-19 | |||
| WO2015163485A1 | 2015-10-29 | |||
| WO2016208775A1 | 2016-12-29 | |||
| WO2015190564A1 | 2015-12-17 |
Foreign References:
| JP2013514358A | 2013-04-25 | |||
| JP2006045220A | 2006-02-16 | |||
| JPH09263545A | 1997-10-07 | |||
| JP2017120859A | 2017-07-06 | |||
| JP2018005960A | 2018-01-11 | |||
| USPP62683418P |
Other References:
ROOK, J. M. ET AL.: "Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of Ml Ago-PAMs", ACS CHEMICAL NEUROSCIENCE, vol. 8, no. 4, 21 December 2016 (2016-12-21), pages 866 - 883, XP055568055, ISSN: 1948-7193
JOURNAL OF CHEMICAL NEUROANATOMY, vol. 33, no. 4, July 2007 (2007-07-01), pages 193 - 201
L.F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory, A Collection of Standard Experimental Procedures", vol. I - VII, 1989, JOHN WILEY & SONS INC
THEODORA W. GREENEPETER G.M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
TETRAHEDRON, vol. 73, 2017, pages 785 - 793
"Design of Molecules", vol. 7, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
ADACHI Y. ET AL.: "Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein", PHARM. RES., vol. 18, 2001, pages 1660 - 1668
TAKEUCHI T.YOSHITOMI S.HIGUCHI T.IKEMOTO K.NIWA S.EBIHARA T.KATOH M.YOKOI T.ASAHI S.: "Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1", PHARM. RES., vol. 23, no. 7, 2006, pages 1460 - 1472, XP019405153, DOI: 10.1007/s11095-006-0285-7
SUGIMOTO H.HIRABAYASHI H.KIMURA Y.FURUTA A.AMANO N.MORIWAKI T.: "Quantitative investigation of the impact of P-glycoprotein inhibition on drug transport across blood-brain barrier in rats", DRUG METAB. DISPOS., vol. 39, no. 1, 2011, pages 8 - 14
JOURNAL OF CHEMICAL NEUROANATOMY, vol. 33, no. 4, July 2007 (2007-07-01), pages 193 - 201
L.F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory, A Collection of Standard Experimental Procedures", vol. I - VII, 1989, JOHN WILEY & SONS INC
THEODORA W. GREENEPETER G.M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
TETRAHEDRON, vol. 73, 2017, pages 785 - 793
"Design of Molecules", vol. 7, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
ADACHI Y. ET AL.: "Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein", PHARM. RES., vol. 18, 2001, pages 1660 - 1668
TAKEUCHI T.YOSHITOMI S.HIGUCHI T.IKEMOTO K.NIWA S.EBIHARA T.KATOH M.YOKOI T.ASAHI S.: "Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1", PHARM. RES., vol. 23, no. 7, 2006, pages 1460 - 1472, XP019405153, DOI: 10.1007/s11095-006-0285-7
SUGIMOTO H.HIRABAYASHI H.KIMURA Y.FURUTA A.AMANO N.MORIWAKI T.: "Quantitative investigation of the impact of P-glycoprotein inhibition on drug transport across blood-brain barrier in rats", DRUG METAB. DISPOS., vol. 39, no. 1, 2011, pages 8 - 14
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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