Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/022179
Kind Code:
A1
Abstract:
To provide a heterocyclic compound which can exhibit an antagonistic action to NR2B subunit-containing NMDA receptors and, therefore, is expected to be useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, symptoms peripheral to dementia, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof.
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Inventors:
KIMURA EIJI (JP)
OGINO MASAKI (JP)
KOHARA YASUHISA (JP)
OHASHI TOMOKO (JP)
KAKU TOMOHIRO (JP)
OGURO YUYA (JP)
MATSUMOTO SHIGEMITSU (JP)
WAKABAYASHI TAKESHI (JP)
TOKUNAGA NORIHITO (JP)
KAMEI TAKU (JP)
ITO MITSUHIRO (JP)
OGINO MASAKI (JP)
KOHARA YASUHISA (JP)
OHASHI TOMOKO (JP)
KAKU TOMOHIRO (JP)
OGURO YUYA (JP)
MATSUMOTO SHIGEMITSU (JP)
WAKABAYASHI TAKESHI (JP)
TOKUNAGA NORIHITO (JP)
KAMEI TAKU (JP)
ITO MITSUHIRO (JP)
Application Number:
PCT/JP2018/028035
Publication Date:
January 31, 2019
Filing Date:
July 26, 2018
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D231/56; A61K31/4162; A61K31/4184; A61K31/4192; A61K31/4439; A61P25/04; A61P25/06; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C07D235/06; C07D235/08; C07D249/18; C07D401/12; C07D409/12
Domestic Patent References:
| WO2016104434A1 | 2016-06-30 | |||
| WO2003035641A1 | 2003-05-01 | |||
| WO2011109441A1 | 2011-09-09 | |||
| WO2014172044A1 | 2014-10-23 | |||
| WO2012123471A1 | 2012-09-20 | |||
| WO1998001429A1 | 1998-01-15 | |||
| WO2000021920A1 | 2000-04-20 | |||
| WO2016104434A1 | 2016-06-30 | |||
| WO2001000663A2 | 2001-01-04 |
Foreign References:
| JP2006522794A | 2006-10-05 | |||
| JP2008508248A | 2008-03-21 | |||
| JP2013522171A | 2013-06-13 | |||
| US20050137187A1 | 2005-06-23 | |||
| US20050137187A1 | 2005-06-23 | |||
| JPH11514333A | 1999-12-07 | |||
| JP2001500852A | 2001-01-23 | |||
| JP2017146744A | 2017-08-24 |
Other References:
BORZA, I. ET AL.: "Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 4638 - 4640, XP005574652
NEURON, vol. 12, 1994, pages 529 - 540
THE JOURNAL OF COMPARATIVE NEUROLOGY (J. COMP. NEUROL., vol. 338, 1993, pages 377 - 390
MOLECULES AND CELLS (MOL. CELLS, vol. 7, 1997, pages 64 - 71
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (THER. ADV. PSYCHOPHARMACOL., vol. 4, 2014, pages 75 - 99
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (J. CLIN. PSYCHOPHARMACOL., vol. 28, 2008, pages 631 - 637
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (J. PHARMACOL. EXP. THER., vol. 321, 2007, pages 564 - 572
EUROPEAN JOURNAL OF NEUROSCIENCE (EUR. J. NEUROSCI., vol. 32, 2010, pages 798 - 810
PAIN, vol. 153, 2012, pages 1022 - 1029
ANNALS OF PHARMACOTHERAPY (ANN. PHARMACOTHER., vol. 42, 2007, pages 32 - 38
JOURNAL OF THE NEUROLOGICAL SCIENCES (J. NEUROL. SCI., vol. 337, 2014, pages 162 - 166
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
L. F. TIETZETH. EICHER: "Shinjikken Kagaku Kouza (Courses in Experimental Chemistry", vol. I - VII, JOHN WILEY & SONS INC, article "A Collection of Standard Experimental Procedures"
KIYOSHI TOMIOKA: "Strategic Applications of Named Reactions in Organic Synthesis", vol. 1, 14, 1989, VCH PUBLISHERS INC.
THEODORA W. GREENEPETER G.M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P. J. KOCIENSKI: "Protecting Groups", 2004, THIEME
See also references of EP 3660003A4
NEURON, vol. 12, 1994, pages 529 - 540
THE JOURNAL OF COMPARATIVE NEUROLOGY (J. COMP. NEUROL., vol. 338, 1993, pages 377 - 390
MOLECULES AND CELLS (MOL. CELLS, vol. 7, 1997, pages 64 - 71
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (THER. ADV. PSYCHOPHARMACOL., vol. 4, 2014, pages 75 - 99
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (J. CLIN. PSYCHOPHARMACOL., vol. 28, 2008, pages 631 - 637
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (J. PHARMACOL. EXP. THER., vol. 321, 2007, pages 564 - 572
EUROPEAN JOURNAL OF NEUROSCIENCE (EUR. J. NEUROSCI., vol. 32, 2010, pages 798 - 810
PAIN, vol. 153, 2012, pages 1022 - 1029
ANNALS OF PHARMACOTHERAPY (ANN. PHARMACOTHER., vol. 42, 2007, pages 32 - 38
JOURNAL OF THE NEUROLOGICAL SCIENCES (J. NEUROL. SCI., vol. 337, 2014, pages 162 - 166
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
L. F. TIETZETH. EICHER: "Shinjikken Kagaku Kouza (Courses in Experimental Chemistry", vol. I - VII, JOHN WILEY & SONS INC, article "A Collection of Standard Experimental Procedures"
KIYOSHI TOMIOKA: "Strategic Applications of Named Reactions in Organic Synthesis", vol. 1, 14, 1989, VCH PUBLISHERS INC.
THEODORA W. GREENEPETER G.M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P. J. KOCIENSKI: "Protecting Groups", 2004, THIEME
See also references of EP 3660003A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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