Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/122092
Kind Code:
A1
Abstract:
The present invention provides a heterocyclic compound having orexin receptor type 2 agonist activity. A compound represented by formula (I) [in the formula, each symbol is as described in the description] or a salt thereof has orexin receptor type 2 agonist activity and is useful as a prophylactic or therapeutic agent for narcolepsy.
Inventors:
MIYANOHANA YUHEI (JP)
KAJITA YUICHI (JP)
KOIKE TATSUKI (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
TOKUNAGA NORIHITO (JP)
ODA TSUNEO (JP)
MIYAZAKI TOHRU (JP)
AINIWAER DILIHUMAER (JP)
ITO YOSHITERU (JP)
TAKEUCHI KOHEI (JP)
IMAMURA KEISUKE (JP)
SUGIMOTO TAKAHIRO (JP)
FUKUDA KOICHIRO (JP)
KOHARA YASUHISA (JP)
OKAMOTO REI (JP)
OHRA TAIICHI (JP)
MIYAMOTO NAOKI (JP)
CHIBA JUN (JP)
TERAO YOSHITO (JP)
KAWASAKI MASANORI (JP)
KAJITA YUICHI (JP)
KOIKE TATSUKI (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
TOKUNAGA NORIHITO (JP)
ODA TSUNEO (JP)
MIYAZAKI TOHRU (JP)
AINIWAER DILIHUMAER (JP)
ITO YOSHITERU (JP)
TAKEUCHI KOHEI (JP)
IMAMURA KEISUKE (JP)
SUGIMOTO TAKAHIRO (JP)
FUKUDA KOICHIRO (JP)
KOHARA YASUHISA (JP)
OKAMOTO REI (JP)
OHRA TAIICHI (JP)
MIYAMOTO NAOKI (JP)
CHIBA JUN (JP)
TERAO YOSHITO (JP)
KAWASAKI MASANORI (JP)
Application Number:
PCT/JP2019/048384
Publication Date:
June 18, 2020
Filing Date:
December 11, 2019
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61K31/437; A61K31/4375; A61K31/444; A61K31/472; A61K31/4985; A61K31/502; A61K31/517; A61K31/519; A61K31/5383; A61P25/26; A61P43/00; C07D217/24; C07D237/28; C07D237/32; C07D239/90; C07D401/10; C07D403/10; C07D405/10; C07D417/10; C07D455/02; C07D471/04; C07D498/04
Domestic Patent References:
| WO2017135306A1 | 2017-08-10 | |||
| WO2015073707A1 | 2015-05-21 | |||
| WO2015048091A1 | 2015-04-02 | |||
| WO2015147240A1 | 2015-10-01 | |||
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Foreign References:
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Other References:
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JANA JANOCKOVA, ET AL: "Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods", MOLECULES, vol. 23, no. 11, 1 January 2018 (2018-01-01), pages 2926, XP055720169, DOI: 10.3390/molecules23112926
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THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
JANA JANOCKOVA, ET AL: "Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods", MOLECULES, vol. 23, no. 11, 1 January 2018 (2018-01-01), pages 2926, XP055720169, DOI: 10.3390/molecules23112926
CELL, vol. 92, 1998, pages 573 - 585
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
L. F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. 1 - 14, 1989, JOHN WILEY & SONS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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