Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/158762
Kind Code:
A1
Abstract:
Provided are: a heterocyclic compound having an HDAC inhibiting activity and useful for the treatment of, for example, central nervous system diseases including neurodegenerative diseases; and a medicine comprising the heterocyclic compound. The present invention relates to a compound represented by formula (I) [wherein the symbols are as defined in the description] or a salt thereof.
Inventors:
ITO MASAHIRO (JP)
YAMAMOTO TAKESHI (JP)
KAKEGAWA KEIKO (JP)
SUGIYAMA HIDEYUKI (JP)
MIYAZAKI TOHRU (JP)
ARIKAWA YASUYOSHI (JP)
OKAWA TOMOHIRO (JP)
YONEMORI JINICHI (JP)
KUBO OSAMU (JP)
TOITA AKINORI (JP)
KOJIMA TAKUTO (JP)
KIKUCHI FUMIAKI (JP)
SASAKI MINORU (JP)
HOMMA MISAKI (JP)
IMAEDA YASUHIRO (JP)
MAEZAKI HIRONOBU (JP)
SASAKI SHINOBU (JP)
SATO AYUMU (JP)
KAMITANI HIROTAKA (JP)
ASANO YASUTOMI (JP)
KOKUBO HIRONORI (JP)
YOSHIKAWA MASATO (JP)
YAMAMOTO TAKESHI (JP)
KAKEGAWA KEIKO (JP)
SUGIYAMA HIDEYUKI (JP)
MIYAZAKI TOHRU (JP)
ARIKAWA YASUYOSHI (JP)
OKAWA TOMOHIRO (JP)
YONEMORI JINICHI (JP)
KUBO OSAMU (JP)
TOITA AKINORI (JP)
KOJIMA TAKUTO (JP)
KIKUCHI FUMIAKI (JP)
SASAKI MINORU (JP)
HOMMA MISAKI (JP)
IMAEDA YASUHIRO (JP)
MAEZAKI HIRONOBU (JP)
SASAKI SHINOBU (JP)
SATO AYUMU (JP)
KAMITANI HIROTAKA (JP)
ASANO YASUTOMI (JP)
KOKUBO HIRONORI (JP)
YOSHIKAWA MASATO (JP)
Application Number:
PCT/JP2020/003063
Publication Date:
August 06, 2020
Filing Date:
January 29, 2020
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61K31/4245; A61K31/4375; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4725; A61K31/497; A61K31/501; A61K31/5025; A61K31/504; A61K31/506; A61K31/536; A61K31/5377; A61P25/02; A61P25/28; A61P43/00; C07D413/04; C07D413/14; C07D417/14; C07D471/04
Domestic Patent References:
| WO2016031815A1 | 2016-03-03 | |||
| WO2017014321A1 | 2017-01-26 | |||
| WO2017014170A1 | 2017-01-26 | |||
| WO2017033946A1 | 2017-03-02 | |||
| WO2017018803A1 | 2017-02-02 | |||
| WO2017018804A1 | 2017-02-02 | |||
| WO2017018805A1 | 2017-02-02 | |||
| WO2017023133A2 | 2017-02-09 | |||
| WO2017065473A1 | 2017-04-20 | |||
| WO2018165520A1 | 2018-09-13 | |||
| WO2019027054A1 | 2019-02-07 | |||
| WO2016031815A1 | 2016-03-03 | |||
| WO2017014321A1 | 2017-01-26 | |||
| WO2017014170A1 | 2017-01-26 | |||
| WO2017033946A1 | 2017-03-02 | |||
| WO2017018803A1 | 2017-02-02 | |||
| WO2017018804A1 | 2017-02-02 | |||
| WO2017018805A1 | 2017-02-02 | |||
| WO2017023133A2 | 2017-02-09 | |||
| WO2018165520A1 | 2018-09-13 | |||
| WO2019027054A1 | 2019-02-07 |
Foreign References:
| JP2019014893A | 2019-01-31 |
Other References:
FRONT CELL NEUROSCI, vol. 9, 2015, pages 343
NEUROMOLECULAR MED., vol. 2, 2002, pages 89 - 99
COLD SPRING HARB PERSPECT MED., vol. 2, 2012, pages a006254
NATURE, vol. 417, 2002, pages 455 - 458
PROC NATL ACAD SCI U S A., vol. 107, 2010, pages 21238 - 21239
ALZHEIMERS RES THER, vol. 6, 2014, pages 12
KIYOSHI TOMIOKA, KAGAKUDOJIN: "Comprehensive Heterocyclic Chemistry III", vol. 1 - Vol.14, 1989, VCH PUBLISHERS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3919055A4
NEUROMOLECULAR MED., vol. 2, 2002, pages 89 - 99
COLD SPRING HARB PERSPECT MED., vol. 2, 2012, pages a006254
NATURE, vol. 417, 2002, pages 455 - 458
PROC NATL ACAD SCI U S A., vol. 107, 2010, pages 21238 - 21239
ALZHEIMERS RES THER, vol. 6, 2014, pages 12
KIYOSHI TOMIOKA, KAGAKUDOJIN: "Comprehensive Heterocyclic Chemistry III", vol. 1 - Vol.14, 1989, VCH PUBLISHERS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
See also references of EP 3919055A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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