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Title:
HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2012/029032
Kind Code:
A3
Abstract:
The present invention relates to heterocyclic compounds of Formula (1), in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, solvates, polymorphs, prodrugs, carboxylic acid isosteres and N-oxides. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

Inventors:
SHARMA RAJIV (IN)
KADAM KISHORKUMAR SHIVAJIRAO (IN)
JADHAV RAVINDRA DNYANDEV (IN)
KANDRE SHIVAJI SADASHIV (IN)
GUPTE AMOL (IN)
Application Number:
PCT/IB2011/053810
Publication Date:
May 18, 2012
Filing Date:
August 31, 2011
Export Citation:
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Assignee:
PIRAMAL LIFE SCIENCES LTD (IN)
SHARMA RAJIV (IN)
KADAM KISHORKUMAR SHIVAJIRAO (IN)
JADHAV RAVINDRA DNYANDEV (IN)
KANDRE SHIVAJI SADASHIV (IN)
GUPTE AMOL (IN)
International Classes:
C07D231/12; A61K31/4164; A61K31/421; A61K31/4245; A61K31/426; C07D263/32; C07D263/34; C07D271/06; C07D271/10; C07D277/30; C07D277/56; C07D285/12; C07D417/04; C07D417/08; C07D417/12
Domestic Patent References:
WO2010023609A12010-03-04
WO2007137107A22007-11-29
WO2008134693A12008-11-06
WO2010059606A22010-05-27
WO2011031628A12011-03-17
Foreign References:
JP2007045752A2007-02-22
Other References:
R. D. HAUGWITZ ET AL: "Antiparasitic agents. 6. Synthesis and anthelmintic activities of novel isothiocyanatophenyl-1,2,4-oxadiazoles", JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, no. 9, 1 September 1985 (1985-09-01), pages 1234 - 1241, XP055017432, ISSN: 0022-2623, DOI: 10.1021/jm00147a019
HA J D ET AL: "Efficient synthesis of 2-imidazol-2-ylacetates", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 47, no. 35, 28 August 2006 (2006-08-28), pages 6201 - 6204, XP025004730, ISSN: 0040-4039, [retrieved on 20060828], DOI: 10.1016/J.TETLET.2006.06.155
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