Title:
HETEROCYCLIC COMPOUNDS AS HPK1 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2022/188735
Kind Code:
A1
Abstract:
Provided are heterocyclics as inhibitors of HPK1, in particular a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising said compound that is useful for treatment of HPK1 mediated diseases and conditions such as cancer.
Inventors:
WANG ZHAOYIN (CA)
SHAO YANQIANG (CN)
LI LINTONG (US)
LI NANXIN (US)
SHAO YANQIANG (CN)
LI LINTONG (US)
LI NANXIN (US)
Application Number:
PCT/CN2022/079503
Publication Date:
September 15, 2022
Filing Date:
March 07, 2022
Export Citation:
Assignee:
GUANGDONG NEWOPP BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07D413/04; A61K31/506; A61P35/00; C07D239/48; C07D405/12; C07D413/14; C07D417/14; C07D491/04; C07D493/10
Domestic Patent References:
| WO2008009458A1 | 2008-01-24 | |||
| WO2010085684A1 | 2010-07-29 | |||
| WO2004037814A1 | 2004-05-06 | |||
| WO2009071535A1 | 2009-06-11 | |||
| WO2019090198A1 | 2019-05-09 |
Foreign References:
| EP1518855A1 | 2005-03-30 | |||
| CN111732548A | 2020-10-02 |
Other References:
DEGNAN ANDREW P., KUMI GODWIN K., ALLARD CHRISTOPHER W., ARAUJO ERIKA V., JOHNSON WALTER L., ZIMMERMANN KURT, PEARCE BRADLEY C., S: "Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 3, 11 March 2021 (2021-03-11), US , pages 443 - 450, XP055964950, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.0c00660
Attorney, Agent or Firm:
SHANGHAI ZHIXIN PATENT AGENT LTD. (CN)
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