Title:
HETEROCYCLIC COMPOUNDS USEFUL AS KRAS G12D INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2023/284881
Kind Code:
A1
Abstract:
Disclosed are compounds of Formula (I0) or Fornula (I), or a salt thereof, methods of using such compounds to modulate or inhibit the activity of KRAS G12D mutant protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of various diseases or conditions, such as cancers.
Inventors:
FANG HAIQUAN (US)
LIU XIAOLEI (CN)
YANG HUI (CN)
LIU XIAOLEI (CN)
YANG HUI (CN)
Application Number:
PCT/CN2022/106215
Publication Date:
January 19, 2023
Filing Date:
July 18, 2022
Export Citation:
Assignee:
SILEXON AI TECH CO LTD (CN)
International Classes:
C07D471/08; A61K31/519; A61P35/00; C07D471/04; C07D487/04; C07D487/08
Domestic Patent References:
| WO2022161443A1 | 2022-08-04 | |||
| WO2022170999A1 | 2022-08-18 | |||
| WO2022171143A1 | 2022-08-18 | |||
| WO2022173870A1 | 2022-08-18 | |||
| WO2022098625A1 | 2022-05-12 | |||
| WO2022061251A1 | 2022-03-24 | |||
| WO2022068921A1 | 2022-04-07 | |||
| WO2022148421A1 | 2022-07-14 | |||
| WO2021106231A1 | 2021-06-03 | |||
| WO2022042630A1 | 2022-03-03 | |||
| WO2022015375A1 | 2022-01-20 | |||
| WO2022066646A1 | 2022-03-31 | |||
| WO2021041671A1 | 2021-03-04 |
Other References:
WANG XIAOLUN, ALLEN SHELLEY, BLAKE JAMES F., BOWCUT VICKIE, BRIERE DAVID M., CALINISAN ANDREW, DAHLKE JOSHUA R., FELL JAY B., FISC: "Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, no. 4, 24 February 2022 (2022-02-24), US , pages 3123 - 3133, XP055952002, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01688
DATABASE REGISTRY 25 April 2022 (2022-04-25), ANONYMOUS : "3,8-Diazabicyclo[3.2.1]octane-6-carbonitrile, 3-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2- pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-, (1R,5S,6S)- (CA INDEX NAME)", XP093024876, retrieved from STN Database accession no. 2766210-67-5
DATABASE REGISTRY 25 April 2022 (2022-04-25), ANONYMOUS : "3,8-Diazabicyclo[3.2.1]octane-6-carbonitrile, 3-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2- pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-, (1R,5S,6S)- (CA INDEX NAME)", XP093024876, retrieved from STN Database accession no. 2766210-67-5
Attorney, Agent or Firm:
BEIJING HUIZE INTELLECTUAL PROPERTY LAW LLC (CN)
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