Title:
HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL DRUG
Document Type and Number:
WIPO Patent Application WO/2013/024898
Kind Code:
A1
Abstract:
The primary purpose of the present invention is to provide a novel heterocyclic derivative or a pharmaceutically acceptable salt thereof. Examples of the present invention can include a heterocyclic compound represented by general formula (1), a tautomer thereof, or a pharmaceutically acceptable salt thereof. (In the formula, R1 and R2 are identical or different and represent an aromatic ring or the like, and the ring (A) represents a heterocycle.) This compound or pharmaceutically acceptable salt thereof has high mPGES-1 inhibitory activity and can be used as a prophylactic agent or therapeutic agent for diseases involving mPGES-1, e.g., rheumatoid arthritis, osteoarthritis, temporomandibular joint disease, low back pain, endometriosis, dysmenorrhea, overactive bladder, malignancy, or neurodegenerative disease.
Inventors:
OTSU HIRONORI (JP)
Application Number:
PCT/JP2012/070902
Publication Date:
February 21, 2013
Filing Date:
August 17, 2012
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
OTSU HIRONORI (JP)
OTSU HIRONORI (JP)
International Classes:
C07D235/06; A61K31/343; A61K31/416; A61K31/4184; A61K31/423; A61K31/428; A61K31/433; A61K31/4439; A61K31/454; A61K31/496; A61K31/5377; A61P1/02; A61P1/04; A61P1/18; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/00; A61P13/10; A61P13/12; A61P15/00; A61P15/04; A61P15/06; A61P15/08; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P25/00; A61P25/06; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P31/16; A61P31/18; A61P31/22; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D231/56; C07D235/08; C07D235/10; C07D235/12; C07D235/14; C07D235/26; C07D263/56; C07D307/79; C07D401/12; C07D403/04; C07D403/12; C07D405/04; C07D405/12; C07D409/12; C07D413/12; C07D417/12
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See also references of EP 2746265A4
TANIKAWA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 291, 2002, pages 884 - 889
TANIOKA ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 32775 - 32782
MURAKAMI ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 32783 - 32792
KAMEI ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 33684 - 33695
KOJIMA ET AL., J. IMMUNOL., vol. 108, 2008, pages 3861 - 3868
KIMURA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 106, 2000, pages 21807 - 21812
ENGBLOM ET AL., NAT. NEUROSCI., vol. 6, 2003, pages 1137 - 1138
FOUDI ET AL., CARDIOVASC. RES., vol. 81, 2009, pages 269 - 277
CHENG ET AL., J. CLIN. INVEST., vol. 116, 2006, pages 1391 - 1399
J. BIOL. CHEM., vol. 279, no. 13, 2004, pages 12647 - 12658
BIOMED. PHARMACOTHER., vol. 65, no. 1, 2011, pages 77 - 84
ACTA. MED. OKAYAMA, vol. 62, no. 6, 2008, pages 373 - 378
PROC. NATL. ACAD. SCI. USA, vol. 106, 2009, pages 21807 - 21812
J. BIOL. CHEM., vol. 279, no. 32, pages 33684 - 33695
J. IMMUNOL., vol. 180, 2008, pages 8361 - 8368
GLIA, vol. 59, 2011, pages 208 - 218
J. BURN. CARE. RES., vol. 32, no. 1, 2011, pages 79 - 90
J. BIOL. CHEM., vol. 278, no. 21, 2003, pages 19396 - 19405
ONCOGENE, vol. 31, no. 24, 2012, pages 2943 - 2952
CANCER RES., vol. 68, no. 9, 2008, pages 3251 - 3259
PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 14507 - 14512
PROC. NATL. ACAD. SCI. USA, vol. 103, no. 31, 2006, pages 11790 - 11795
J. RHEUMATOL., vol. 32, no. 5, 2005, pages 887 - 895
J. PHARMACOL. EXP. THER., vol. 326, 2008, pages 754 - 763
KIDNEY INT., vol. 79, no. 1, 2011, pages 77 - 88
J. IMMUNOL., vol. 188, 2012, pages 4093 - 4102
AM. J. PHYSIOL. LUNG CELL MOL. PHYSIOL., vol. 287, 2004, pages L981 - L991
AM. J. PHYSIOL. LUNG CELL MOL. PHYSIOL., vol. 288, 2005, pages L1010 - L1016
ARTHRITIS RES. THER., vol. 13, 2011, pages R6
J. ORG. CHEM., vol. 25, 1960, pages 942
J. MED. CHEM., vol. 42, 1999, pages 5020
BIOORG. MED. CHEM., vol. 7, 1999, pages 2271
J. MED. CHEM., vol. 36, 1993, pages 2182
EUR. J. MED. CHEM., vol. 34, 1999, pages 729
TETRAHEDRON ASYMMETRY, vol. 18, 2007, pages 2011
BULL. CHEM. SOC. JPN., vol. 74, 2001, pages 1695
J. AM. CHEM. SOC., vol. 96, 1974, pages 1518
BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 2204
TETRAHEDRON LETT., vol. 38, 1997, pages 2259
J. MED. CHEM., vol. 48, 2005, pages 2080
BRIDEAU ET AL., INFLAMM. RES., vol. 45, 1996, pages 68
See also references of EP 2746265A4
Attorney, Agent or Firm:
SHIMIZU, NAOTO (JP)
Hisato Shimizu (JP)
Hisato Shimizu (JP)
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