Title:
HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2023/025116
Kind Code:
A1
Abstract:
The present invention relates to a heterocyclic derivative, a preparation method therefor and the use thereof in medicine. Specifically, the present invention relates to a heterocyclic derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof, as well as the use thereof as a therapeutic agent, especially as a KRas G12D inhibitor; the definitions of each substituent in general formula (I) are the same as the definitions thereof in the description.
Inventors:
CHEN YOUXI (CN)
HUANG XIANGUI (CN)
GONG LIANG (CN)
LI WENPENG (CN)
MAO WENTAO (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)
HUANG XIANGUI (CN)
GONG LIANG (CN)
LI WENPENG (CN)
MAO WENTAO (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)
Application Number:
PCT/CN2022/114084
Publication Date:
March 02, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
A61K31/519; C07D519/00; A61P35/00; A61P35/02; C07C51/41; C07C53/18; C07D471/04; C07F7/18
Domestic Patent References:
| WO2021041671A1 | 2021-03-04 | |||
| WO2020146613A1 | 2020-07-16 | |||
| WO2018064510A1 | 2018-04-05 |
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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