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Title:
HETEROCYCLIC DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/123316
Kind Code:
A1
Abstract:
Disclosed is an sGC activator, particularly a compound which is useful for the prevention or treatment of diseases including hypertension, ischemic heart diseases, heart failure, kidney diseases, arteriosclerotic diseases, atrial fibrillation, plumonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial disease and erectile dysfunction and has excellent pharmacological activities, excellent physicochemical properties and others. Specifically disclosed is an sGC activator comprising a compound represented by general formula (II) [wherein each symbol is as defined in the description] or a salt thereof as an active ingredient.

Inventors:
MATSUNAGA NOBUYUKI (JP)
NAKADA YOSHIHISA (JP)
OHBA YUSUKE (JP)
NAKAGAWA HIDEYUKI (JP)
Application Number:
PCT/JP2009/056994
Publication Date:
October 08, 2009
Filing Date:
April 03, 2009
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICAL (JP)
MATSUNAGA NOBUYUKI (JP)
NAKADA YOSHIHISA (JP)
OHBA YUSUKE (JP)
NAKAGAWA HIDEYUKI (JP)
International Classes:
C07D263/32; A61K31/341; A61K31/421; A61K31/4245; A61K31/426; A61K31/427; A61K31/433; A61K31/506; A61P1/00; A61P1/04; A61P1/06; A61P1/14; A61P1/16; A61P3/00; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P7/02; A61P7/10; A61P9/00; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/08; A61P11/16; A61P13/08; A61P13/12; A61P15/00; A61P15/10; A61P15/12; A61P17/00; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P35/04; A61P37/02; A61P37/08; A61P43/00; C07D271/04; C07D271/10; C07D277/20; C07D277/30; C07D285/12; C07D307/54; C07D417/04; C07D417/06; C07D417/14
Domestic Patent References:
WO2003002062A22003-01-09
WO2006097625A12006-09-21
WO2007055941A22007-05-18
WO2003076408A22003-09-18
WO2000027394A12000-05-18
WO2009032249A12009-03-12
WO2009032249A12009-03-12
WO2004056815A12004-07-08
WO1992016527A11992-10-01
WO2001038325A12001-05-31
WO2001025228A12001-04-12
WO2003042204A12003-05-22
WO1998044921A11998-10-15
WO1998045285A11998-10-15
WO1999022735A11999-05-14
WO2001014372A22001-03-01
WO2002006264A12002-01-24
WO2003059900A12003-07-24
WO2001082925A12001-11-08
WO2001087834A12001-11-22
WO2004048363A12004-06-10
Foreign References:
JP2003231679A2003-08-19
DE19834110A12000-02-03
US5342851A1994-08-30
JPH11302277A1999-11-02
US20080319012A12008-12-25
US6335334B12002-01-01
US7087644B12006-08-08
US20070179139A12007-08-02
US20080058314A12008-03-06
US20060122181A12006-06-08
US20030104324A12003-06-05
US20050065196A12005-03-24
JPH04154773A1992-05-27
US20060205731A12006-09-14
Other References:
SANFILIPPO, P. J.: "Novel Thiazole-Based Heterocycles as Selective Inhibitors of Fibrinogen-Mediated Platelet Aggregation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 1, 1995, pages 34 - 41, XP009077038, DOI: doi:10.1021/jm00001a008
See also references of EP 2264017A4
"Pharmaceutical Research and Development", vol. 7, 1990, HIROKAWA PUBLISHING CO., pages: 163 - 198
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 285, 2001, pages 2486 - 2497
CANCER RESEARCH, vol. 49, 1989, pages 5935 - 5939
JOURNAL OF CLINICAL ONCOLOGY, vol. 12, 1994, pages 213 - 225
BRITISH JOURNAL OF CANCER, vol. 68, 1993, pages 314 - 318
TETRAHEDRON LETTERS, vol. 39, 1998, pages 2933
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
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