Title:
HETEROCYCLIC DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/149767
Kind Code:
A1
Abstract:
Provided are: a heterocyclic derivative and/or a pharmaceutically acceptable salt thereof that can serve as a therapeutic agent and/or a prophylactic agent for a disease in which the sodium channel (Nav) is involved and for various central nervous system disorders; and a pharmaceutical agent that includes the heterocyclic derivative and/or a pharmaceutically acceptable salt thereof as an active ingredient. Also provided are: a heterocyclic derivative and/or a pharmaceutically acceptable salt thereof that can serve as a therapeutic agent and/or a prophylactic agent for tauopathy, the agents functioning by activating Nav; and a pharmaceutical agent that includes the heterocyclic derivative and/or a pharmaceutically acceptable salt thereof as an active ingredient. Further provided is a heterocyclic derivative and/or a pharmaceutically acceptable salt thereof that can serve as a pharmaceutical agent and that is represented by formula (I) [in the formula, Y1, Y2, Y3, M1, and M2 are as defined in this description]; and a therapeutic agent and/or a prophylactic agent that includes the heterocyclic derivative and/or a pharmaceutically acceptable salt thereof as an active ingredient, and that is for a disease in which the sodium channel is involved, for various central nervous system disorders, and/or for tauopathy.
Inventors:
IWAMOTO KOHEI (JP)
SHIBATA HAJIME (JP)
UEMACHI HIRO (JP)
NISHIDA TOMOAKI (JP)
IKEDA JUNYA (JP)
SHIBATA HAJIME (JP)
UEMACHI HIRO (JP)
NISHIDA TOMOAKI (JP)
IKEDA JUNYA (JP)
Application Number:
PCT/JP2021/002044
Publication Date:
July 29, 2021
Filing Date:
January 21, 2021
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K45/00; A61K31/4412; A61K31/444; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K31/5395; A61P21/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P43/00; C07D213/64; C07D213/74; C07D241/18; C07D273/04; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/14; C07D409/04; C07D413/06; C07D413/12; C07D413/14; C07D471/04
Domestic Patent References:
| WO2017147379A1 | 2017-08-31 | |||
| WO2020017587A1 | 2020-01-23 |
Other References:
DATABASE REGISTRY 21 September 2021 (2021-09-21), XP055843747, retrieved from STN Database accession no. 2197794-08-2
MAO, H. ET AL.: "Novel Modulator of NaV1.1 and NaVl.2 Na+ Channels in Rat Neuronal Cells", ACS MEDICINAL CHEMISTRY LETTERS, vol. 1, no. 3, 2010, pages 135 - 138, XP055677999, DOI: 10.1021/m1100035t
GILCHRIST, J. ET AL.: "Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents", ACS CHEMICAL BIOLOGY, vol. 9, no. 5, 2014, pages 1204 - 1212, XP055362820, DOI: 10.1021/c11500108p
FRANÇOIS CRESTEY; KRISTEN FREDERIKSEN; HENRIK S JENSEN; KIM DEKERMENDJIAN; PETER H LARSEN; JESPER F BASTLUND; DUNGUO LU; HENRY LIU: "Identification and Electrophysiological Evaluation of 2- Methylllenzamide Derivatives as Nav1.1 Modulators", ACS CHEMICAL NEUROSCIENCE, vol. 6, no. 8, 2015, pages 1302 - 1308, XP055677995, DOI: 10.1021/acschemneuro.51100147
FREDERIKSEN KRISTEN, LU DUNGUO, YANG JINHUI, JENSEN HENRIK SINDAL, BASTLUND JESPER FRANK, LARSEN PETER HJØRRINGGAARD, LIU HENRY, C: "A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 46, no. 3, 2017, pages 1887 - 1896, XP055843494, DOI: 10.1111/ejn.13626
MIYAZAKI, T. ET AL.: "Discovery of novel 4-phenyl- 2-(pyrrolidinyl)nicotinamide derivatives as potent Nav1.1 activators", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, no. 6, 2019, pages 815 - 820, XP002797001, DOI: 10.1016/j.llmcl. 2019.01.02 3
MAO, H. ET AL.: "Novel Modulator of NaV1.1 and NaVl.2 Na+ Channels in Rat Neuronal Cells", ACS MEDICINAL CHEMISTRY LETTERS, vol. 1, no. 3, 2010, pages 135 - 138, XP055677999, DOI: 10.1021/m1100035t
GILCHRIST, J. ET AL.: "Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents", ACS CHEMICAL BIOLOGY, vol. 9, no. 5, 2014, pages 1204 - 1212, XP055362820, DOI: 10.1021/c11500108p
FRANÇOIS CRESTEY; KRISTEN FREDERIKSEN; HENRIK S JENSEN; KIM DEKERMENDJIAN; PETER H LARSEN; JESPER F BASTLUND; DUNGUO LU; HENRY LIU: "Identification and Electrophysiological Evaluation of 2- Methylllenzamide Derivatives as Nav1.1 Modulators", ACS CHEMICAL NEUROSCIENCE, vol. 6, no. 8, 2015, pages 1302 - 1308, XP055677995, DOI: 10.1021/acschemneuro.51100147
FREDERIKSEN KRISTEN, LU DUNGUO, YANG JINHUI, JENSEN HENRIK SINDAL, BASTLUND JESPER FRANK, LARSEN PETER HJØRRINGGAARD, LIU HENRY, C: "A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 46, no. 3, 2017, pages 1887 - 1896, XP055843494, DOI: 10.1111/ejn.13626
MIYAZAKI, T. ET AL.: "Discovery of novel 4-phenyl- 2-(pyrrolidinyl)nicotinamide derivatives as potent Nav1.1 activators", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, no. 6, 2019, pages 815 - 820, XP002797001, DOI: 10.1016/j.llmcl. 2019.01.02 3
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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