HETEROCYCLIC DERIVATIVES AS ALK INHIBITORS

Title:

HETEROCYCLIC DERIVATIVES AS ALK INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2011/138751

Kind Code:

A3

Abstract:

The invention relates to compounds of Formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.

Inventors:

BUNNAGE MARK EDWARD (GB)
COOK ANDREW SIMON (GB)
CUI JINGRONG JEAN (US)
DACK KEVIN NEIL (GB)
DEAL JUDITH GAIL (US)
GU DANLIN (US)
HE MINGYING (US)
JOHNSON PATRICK STEPHEN (GB)
JOHNSON TED WILLIAM (US)
LE PHUONG THI QUY (US)
PALMER CYNTHIA LOUISE (US)
SHEN HONG (US)

Application Number:

PCT/IB2011/051981

Publication Date:

January 19, 2012

Filing Date:

May 04, 2011

Export Citation:

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Assignee:

PFIZER (US)
BUNNAGE MARK EDWARD (GB)
COOK ANDREW SIMON (GB)
CUI JINGRONG JEAN (US)
DACK KEVIN NEIL (GB)
DEAL JUDITH GAIL (US)
GU DANLIN (US)
HE MINGYING (US)
JOHNSON PATRICK STEPHEN (GB)
JOHNSON TED WILLIAM (US)
LE PHUONG THI QUY (US)
PALMER CYNTHIA LOUISE (US)
SHEN HONG (US)

International Classes:

C07D401/04; A61K31/4439; A61K31/444; A61K31/501; C07D401/14; C07D403/04; C07D403/14; C07D409/14; C07D413/04; C07D413/14; C07D417/04; C07D417/14; C07D451/02; C07D498/04; C07F9/53

Domestic Patent References:

WO2006021881A2	2006-03-02
WO2008088881A1	2008-07-24
WO2004076412A2	2004-09-10
WO2008053157A1	2008-05-08

Attorney, Agent or Firm:

KLEIMAN, Gabriel, L. et al. (235 East 42nd StreetNew York, NY, US)

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