Title:
HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY STEAROYL-COA DESATURASE ENZYMES
Document Type and Number:
WIPO Patent Application WO2006034315
Kind Code:
A3
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Inventors:
KAMBOJ RAJENDER (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
KODUMURU VISHNUMURTHY (CA)
LIU SHIFENG (CA)
SUN SHAOYI (CA)
CHAKKA NAGASREE (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
KODUMURU VISHNUMURTHY (CA)
LIU SHIFENG (CA)
SUN SHAOYI (CA)
CHAKKA NAGASREE (CA)
Application Number:
PCT/US2005/033744
Publication Date:
July 27, 2006
Filing Date:
September 20, 2005
Export Citation:
Assignee:
XENON PHARMACEUTICALS INC (CA)
KAMBOJ RAJENDER (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
KODUMURU VISHNUMURTHY (CA)
LIU SHIFENG (CA)
SUN SHAOYI (CA)
CHAKKA NAGASREE (CA)
KAMBOJ RAJENDER (CA)
ZHANG ZAIHUI (CA)
FU JIAN-MIN (CA)
KODUMURU VISHNUMURTHY (CA)
LIU SHIFENG (CA)
SUN SHAOYI (CA)
CHAKKA NAGASREE (CA)
International Classes:
A61K31/381; A61K31/41; A61K31/415; A61P3/04; C07D231/38; C07D271/10; C07D277/28; C07D285/00
Domestic Patent References:
| WO2004058727A1 | 2004-07-15 | |||
| WO2004089416A2 | 2004-10-21 | |||
| WO1999047507A2 | 1999-09-23 | |||
| WO2002074767A1 | 2002-09-26 | |||
| WO2002066446A1 | 2002-08-29 |
Foreign References:
| US20050234046A1 | 2005-10-20 | |||
| US3830924A | 1974-08-20 | |||
| DE10259382A1 | 2004-07-01 | |||
| US5668148A | 1997-09-16 | |||
| US20040147573A1 | 2004-07-29 | |||
| US20030225097A1 | 2003-12-04 |
Other References:
FOROUMADI, A.; SOLTANI, F.; ASGHARIAN REZAEE, M.; MOSHAFI, M.H.: "Synthesis and evaluation of in vitro antimycobacterialactivity of some 5-(5-nitro-2-thienyl)-2-(piperazinyl, piperidinyl and morpholinyl)-1,3,4-thiadiazole derivatives", BOLLETTINO CHIMICO FARMACEUTICO, vol. 142, 2003, pages 416 - 419, XP008064263
ROWLEY M ET AL: "4-Heterocyclylpiperidines as Selective High-Affinity Ligands at the Human Dopamine D4 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, 1997, pages 2374 - 2385, XP002173936, ISSN: 0022-2623
ROWLEY M ET AL: "4-Heterocyclylpiperidines as Selective High-Affinity Ligands at the Human Dopamine D4 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, 1997, pages 2374 - 2385, XP002173936, ISSN: 0022-2623
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