Title:
HETEROCYCLIC DYE COMPOUNDS FOR IN VIVO IMAGING AND DIAGNOSIS OF ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO2006020156
Kind Code:
A3
Abstract:
The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease. The present invention also relates to therapeutic uses for such compounds, as examplified by compounds of the formula (I) in which Y is independently S, O, or N and m is 1, 2, or 3.
Inventors:
BACSKAI BRIAN (US)
HYMAN BRADLEY T (US)
KLUNK WILLIAM E (US)
MATHIS CHESTER A (US)
SWAGER TIMOTHY (US)
NESTEROV EVGUENI (US)
HILLS IVORY (US)
HYMAN BRADLEY T (US)
KLUNK WILLIAM E (US)
MATHIS CHESTER A (US)
SWAGER TIMOTHY (US)
NESTEROV EVGUENI (US)
HILLS IVORY (US)
Application Number:
PCT/US2005/025334
Publication Date:
April 20, 2006
Filing Date:
July 15, 2005
Export Citation:
Assignee:
GEN HOSPITAL CORP (US)
MASSACHUSETTS INST TECHNOLOGY (US)
M OF HIGHER EDUCATION UNIVERSI (US)
BACSKAI BRIAN (US)
HYMAN BRADLEY T (US)
KLUNK WILLIAM E (US)
MATHIS CHESTER A (US)
SWAGER TIMOTHY (US)
NESTEROV EVGUENI (US)
HILLS IVORY (US)
MASSACHUSETTS INST TECHNOLOGY (US)
M OF HIGHER EDUCATION UNIVERSI (US)
BACSKAI BRIAN (US)
HYMAN BRADLEY T (US)
KLUNK WILLIAM E (US)
MATHIS CHESTER A (US)
SWAGER TIMOTHY (US)
NESTEROV EVGUENI (US)
HILLS IVORY (US)
International Classes:
C07D409/04; A61K31/381; A61K31/404; A61K31/4192; A61K31/428; A61K49/00; A61K51/04; A61P25/00; C07D333/18; C07D333/54; C07D409/14; C07D417/14
Domestic Patent References:
| WO2001078723A1 | 2001-10-25 | |||
| WO2003018068A1 | 2003-03-06 | |||
| WO2002016333A2 | 2002-02-28 | |||
| WO2003068269A1 | 2003-08-21 |
Foreign References:
| EP1110945A2 | 2001-06-27 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TOME, A. C.: "Product class 13: 1,2,3-triazoles", XP002353698, retrieved from STN Database accession no. 2004:204626
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BAKHAREVA, S. V. ET AL: "The method of synthesis of furyl- and indolyl-substituted 4-acyl-1,2,3-triazoles", XP002353709, retrieved from STN Database accession no. 2002:200988
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KLIMENKO, V. I. ET AL: "Synthesis and properties of 1-furyl-2-nitropropen-3-ones and -als", XP002353755, retrieved from STN Database accession no. 1980:180902
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SITKIN, A. I. ET AL: "4-Furyl-5-acyl-1,2,3-triazoles", XP002353756, retrieved from STN Database accession no. 1979:168513
SEEBACH, DIETER ET AL: "Reaction of metalated nitrosamines with nitriles. A novel access to v-triazoles", CHEMISCHE BERICHTE , 110(5), 1879-86 CODEN: CHBEAM; ISSN: 0009-2940, 1977, XP002353760
BECK, GERHARD ET AL: "New synthesis of 1,2,3-triazoles", CHEMISCHE BERICHTE , 106(9), 2758-66 CODEN: CHBEAM; ISSN: 0009-2940, 1973, XP002353763
PATENT ABSTRACTS OF JAPAN vol. 010, no. 276 (C - 373) 10 September 1986 (1986-09-10)
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366265
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366266
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366267
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366268
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366269
MIGNANI G ET AL: "SYNTHESIS OF NEW THIOPHENE COMPOUNDS WITH LARGE SECOND ORDER OPTICAL NON-LINEARITIES", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 31, no. 33, 6 August 1990 (1990-08-06), pages 4743 - 4746, XP000226735, ISSN: 0040-4039
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BAKHAREVA, S. V. ET AL: "The method of synthesis of furyl- and indolyl-substituted 4-acyl-1,2,3-triazoles", XP002353709, retrieved from STN Database accession no. 2002:200988
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KLIMENKO, V. I. ET AL: "Synthesis and properties of 1-furyl-2-nitropropen-3-ones and -als", XP002353755, retrieved from STN Database accession no. 1980:180902
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SITKIN, A. I. ET AL: "4-Furyl-5-acyl-1,2,3-triazoles", XP002353756, retrieved from STN Database accession no. 1979:168513
SEEBACH, DIETER ET AL: "Reaction of metalated nitrosamines with nitriles. A novel access to v-triazoles", CHEMISCHE BERICHTE , 110(5), 1879-86 CODEN: CHBEAM; ISSN: 0009-2940, 1977, XP002353760
BECK, GERHARD ET AL: "New synthesis of 1,2,3-triazoles", CHEMISCHE BERICHTE , 106(9), 2758-66 CODEN: CHBEAM; ISSN: 0009-2940, 1973, XP002353763
PATENT ABSTRACTS OF JAPAN vol. 010, no. 276 (C - 373) 10 September 1986 (1986-09-10)
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366265
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366266
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366267
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366268
DATABASE CROSSFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002366269
MIGNANI G ET AL: "SYNTHESIS OF NEW THIOPHENE COMPOUNDS WITH LARGE SECOND ORDER OPTICAL NON-LINEARITIES", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 31, no. 33, 6 August 1990 (1990-08-06), pages 4743 - 4746, XP000226735, ISSN: 0040-4039
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