Title:
HETEROCYCLIC RING AND CARBOCYCLIC DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/118855
Kind Code:
A1
Abstract:
Provided is a novel compound having P2X3 and/or P2X2/3 receptor antagonist activity, for example, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In formula (I), R2 represents a hydrogen atom or the like; ring A represents a five- to seven-membered cycloalkane or the like; C represent a carbon atom; each of Q1 and Q2 represents a carbon atom or the like; each of R9a and R9b represents a hydrogen atom or the like; R6 represents a cycloalkyl or the like; R16 represents a hydrogen atom or the like; and R7 represents a group represented by formula (AA) (wherein ring D represents a benzene or the like; carbon atoms a and b represent carbon atoms; ring B represents an aromatic carbocyclic ring or the like; each of s and s' represents 0 or the like; and each of R9 and R9' represents a halogen or the like) or the like.)
Inventors:
KAI HIROYUKI (JP)
TANAKA SATORU (JP)
HIRAMATSU YOSHIHARU (JP)
HASHIMOTO AZUSA (JP)
NAKAMURA KEN ICHIOH (JP)
TANAKA SATORU (JP)
HIRAMATSU YOSHIHARU (JP)
HASHIMOTO AZUSA (JP)
NAKAMURA KEN ICHIOH (JP)
Application Number:
PCT/JP2013/052991
Publication Date:
August 15, 2013
Filing Date:
February 08, 2013
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D239/54; A61K31/513; A61P11/00; A61P11/06; A61P11/14; A61P13/00; A61P25/04; A61P43/00; C07D401/12; C07D405/12; C07D405/14; C07D417/12
Domestic Patent References:
| WO2012020742A1 | 2012-02-16 | |||
| WO1999052881A1 | 1999-10-21 | |||
| WO2012020749A1 | 2012-02-16 | |||
| WO2010092966A1 | 2010-08-19 |
Foreign References:
| JP2007526268A | 2007-09-13 |
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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Claims: