Title:
HETERODIMER MOLECULE BASED ON CH3 STRUCTURAL DOMAIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/101828
Kind Code:
A1
Abstract:
A heterodimer molecule based on CH3, and a preparation method therefor and a use thereof. By comprehensively considering various interactions between molecules, for example, an ionic action, a hydrophobic interaction and a spatial action, a preferred Fc mutant sequence being more inclined to form a heterodimer rather than a homodimer is screened, and accordingly, the yield of the heterodimer molecule is greatly improved, thereby creating conditions for the preparation of bispecific molecules and the like.
Inventors:
XU TING (CN)
Application Number:
PCT/CN2016/110252
Publication Date:
June 22, 2017
Filing Date:
December 16, 2016
Export Citation:
Assignee:
SUZHOU ALPHAMAB CO LTD (CN)
International Classes:
C07K16/46; A61K39/395; C07K16/00; C12N15/11; C12P21/00
Domestic Patent References:
| WO2009089004A1 | 2009-07-16 | |||
| WO2012131555A2 | 2012-10-04 | |||
| WO2014012085A2 | 2014-01-16 | |||
| WO2011090761A1 | 2011-07-28 |
Foreign References:
| CN102558355A | 2012-07-11 | |||
| CN102851338A | 2013-01-02 |
Other References:
See also references of EP 3392276A4
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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