Title:
HETERODIMERIC POLYPEPTIDE COMPLEXES COMPRISING IL-15 VARIANTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160721
Kind Code:
A1
Abstract:
Provided in the present disclosure are IL-15 variants, IL-15/IL-15Rα-Fc fusion proteins comprising the IL-15 variants and IL-15/IL-15Rα fusion protein comprising the IL-15 variants the methods of producing the same and the uses thereof. The IL-15 variants, fusion proteins, and polypeptide complexes of the disclosure can be used as a potent agent for the treatment of cancers and infectious diseases.
Inventors:
LIANG YU (CN)
SUN MENGMENG (CN)
WU LEI (CN)
XIN RUIPU (CN)
XU JIANQING (CN)
GU JIJIE (CN)
SUN MENGMENG (CN)
WU LEI (CN)
XIN RUIPU (CN)
XU JIANQING (CN)
GU JIJIE (CN)
Application Number:
PCT/CN2023/078743
Publication Date:
August 31, 2023
Filing Date:
February 28, 2023
Export Citation:
Assignee:
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
C07K19/00; A61K38/20; A61P35/00; C07K1/00; C07K14/54; C07K16/28; C12N5/10; C12N15/62; C12N15/63
Domestic Patent References:
| WO2021119429A1 | 2021-06-17 | |||
| WO2021113577A1 | 2021-06-10 |
Foreign References:
| CN112105645A | 2020-12-18 | |||
| CN112368015A | 2021-02-12 | |||
| CN112513070A | 2021-03-16 | |||
| CN112585161A | 2021-03-30 |
Other References:
GUO YIN; LUAN LIMING; PATIL NAEEM K.; SHERWOOD EDWARD R.: "Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent", CYTOKINE & GROWTH FACTOR REVIEWS, ELSEVIER LTD, GB, vol. 38, 1 January 1900 (1900-01-01), GB , pages 10 - 21, XP085253997, ISSN: 1359-6101, DOI: 10.1016/j.cytogfr.2017.08.002
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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