Title:
HETERODIMERIC PROTEIN AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/046047
Kind Code:
A1
Abstract:
Provided are a heterodimeric protein and an application thereof. The heterodimeric protein contains: (1) a light chain and a heavy chain 1, which are compounded to form a target part expressing binding specificity for a tumor antigen or an immune checkpoint, the tumor antigen or the immune checkpoint comprising B7H3; and (2) a heavy chain 2, which contains an Fc region, and an immunomodulator fused with the Fc region, the immunomodulator comprising IL-10. An affinity detection result shows that the heterodimeric protein has relatively high affinity for B7H3 and IL-10 receptors; and an in-vivo efficacy experiment result shows that the heterodimeric protein has good anti-tumor activity.
Inventors:
ZHOU CHONG (CN)
JIANG XIAOLING (CN)
YIN LIUSONG (CN)
JIANG XIAOLING (CN)
YIN LIUSONG (CN)
Application Number:
PCT/CN2022/120730
Publication Date:
March 30, 2023
Filing Date:
September 23, 2022
Export Citation:
Assignee:
SHENGHE CHINA BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07K19/00; A61K39/395; A61P35/00; C07K16/28
Domestic Patent References:
| WO2020127369A1 | 2020-06-25 | |||
| WO2020127377A1 | 2020-06-25 | |||
| WO2018144955A1 | 2018-08-09 | |||
| WO2021185934A1 | 2021-09-23 |
Foreign References:
| CN108727504A | 2018-11-02 | |||
| CN110799542A | 2020-02-14 | |||
| CN110305213A | 2019-10-08 |
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