Title:
HIF HYDROXYLASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2003080566
Kind Code:
A3
Abstract:
The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.
Inventors:
SCHOFIELD CHRISTOPHER JOSEPH (GB)
MAXWELL PATRICK HENRY (GB)
PUGH CHRISTOPHER WILLIAM (GB)
RATCLIFFE PETER JOHN (GB)
MAXWELL PATRICK HENRY (GB)
PUGH CHRISTOPHER WILLIAM (GB)
RATCLIFFE PETER JOHN (GB)
Application Number:
PCT/GB2003/001239
Publication Date:
December 11, 2003
Filing Date:
March 21, 2003
Export Citation:
Assignee:
ISIS INNOVATION (GB)
SCHOFIELD CHRISTOPHER JOSEPH (GB)
MAXWELL PATRICK HENRY (GB)
PUGH CHRISTOPHER WILLIAM (GB)
RATCLIFFE PETER JOHN (GB)
SCHOFIELD CHRISTOPHER JOSEPH (GB)
MAXWELL PATRICK HENRY (GB)
PUGH CHRISTOPHER WILLIAM (GB)
RATCLIFFE PETER JOHN (GB)
International Classes:
A61K31/4015; A61K31/165; A61K31/19; A61K31/194; A61K31/22; A61K31/223; A61P3/00; A61P3/10; A61P9/08; A61P9/10; A61P9/12; A61P17/02; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07D207/46; C07F5/02; (IPC1-7): C07C259/06; C07D207/46; C07C59/347; C07K5/06; C07C309/17; C07F5/02; A61K31/194; A61K31/16; A61K31/33
Domestic Patent References:
WO2002074981A2 | 2002-09-26 | |||
WO2000074725A1 | 2000-12-14 | |||
WO1997024145A1 | 1997-07-10 | |||
WO1999007729A2 | 1999-02-18 |
Foreign References:
EP0344682A2 | 1989-12-06 | |||
EP0228625A2 | 1987-07-15 | |||
US4273779A | 1981-06-16 | |||
EP0148752A2 | 1985-07-17 | |||
US6200974B1 | 2001-03-13 | |||
DE4410453A1 | 1995-09-28 | |||
US4446038A | 1984-05-01 | |||
US4623733A | 1986-11-18 |
Other References:
JAAKOLA ET AL: "Targeting of HIF-alpha to the Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 292, no. 5516, 20 April 2001 (2001-04-20), pages 468 - 472, XP002211146, ISSN: 0036-8075
THOUIN E ET AL: "Effective synthesis of enantiopure hydroxamates by displacement of resin-bound esters with hydroxylamine", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 4, January 2000 (2000-01-01), pages 457 - 460, XP004187102, ISSN: 0040-4039
WALTER M W ET AL: "Synthesis of Metallo-beta-Lactamase Inhibitors", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 21, 26 May 1997 (1997-05-26), pages 7275 - 7290, XP004105706, ISSN: 0040-4020
MAGNUS W. WALTER ET AL.: "Hydroxamate inhibitors of Aeromonas hydrophila AE036 Metallo-beta-lactamase", BIOORGANIC CHEMISTRY, vol. 27, 1999, pages 35 - 40, XP002244402
E. HOFFMANN ET AL.: "A peptide synthesis via hydroxamic acids", JOURNAL OF ORGANIC CHEMISTRY., vol. 29, 1964, EASTON US, pages 748 - 751, XP002244403
MYRON L. BENDER ET AL.: "Sigmoid and bell-shaped pH-rate profiles in alpha-chymotrypsin-catalyzed hydrolyses.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 85, 1963, DC US, pages 358 - 359, XP002244404
CHEMICAL ABSTRACTS, vol. 86, no. 11, 1977, Columbus, Ohio, US; abstract no. 72508v, ZUKOWSKI, EDWARD ET AL.: "Modification of 6-aminopenicillanic acid derivatives." page 603; column 2; XP002244405
BLODGETT J K ET AL: "SPECIFIC CLEAVAGE OF PEPTIDES CONTAINING AN ASPARTIC ACID (BETA-HYDROXAMIC ACID) RESIDUE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 107, no. 14, 1985, pages 4305 - 4313, XP002020788, ISSN: 0002-7863
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002244406
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002244407
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002244408
PATENT ABSTRACTS OF JAPAN vol. 007, no. 201 (C - 184) 6 September 1983 (1983-09-06)
BYOUNG-MOG KWON ET AL.: "Photooxygenation of ascorbic acid derivatives and model compounds", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 111, no. 5, 1989, DC US, pages 1854 - 1860, XP002256128
CHEMICAL ABSTRACTS, vol. 54, no. 11, 10 June 1960, Columbus, Ohio, US; abstract no. 10856d, RUDOLF W. BALSIGER ETAL.: "Synthesis of potential anticancer agents." page 10855; column 2; XP002256130
TAKAYAMA SHUICHI ET AL: "Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferase: donar sugar-nucleotide based approach", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 7, February 1999 (1999-02-01), pages 401 - 409, XP002963943, ISSN: 0968-0896
ROBERT S. WEHBIE ET AL.: "Rat liver-gamma-butyrobetaine hydroxylase catalyzed reaction", BIOCHEMISTRY., vol. 27, no. 6, 1988, EASTON, PA US, pages 2222 - 2228, XP002256129
THOUIN E ET AL: "Effective synthesis of enantiopure hydroxamates by displacement of resin-bound esters with hydroxylamine", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 4, January 2000 (2000-01-01), pages 457 - 460, XP004187102, ISSN: 0040-4039
WALTER M W ET AL: "Synthesis of Metallo-beta-Lactamase Inhibitors", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 21, 26 May 1997 (1997-05-26), pages 7275 - 7290, XP004105706, ISSN: 0040-4020
MAGNUS W. WALTER ET AL.: "Hydroxamate inhibitors of Aeromonas hydrophila AE036 Metallo-beta-lactamase", BIOORGANIC CHEMISTRY, vol. 27, 1999, pages 35 - 40, XP002244402
E. HOFFMANN ET AL.: "A peptide synthesis via hydroxamic acids", JOURNAL OF ORGANIC CHEMISTRY., vol. 29, 1964, EASTON US, pages 748 - 751, XP002244403
MYRON L. BENDER ET AL.: "Sigmoid and bell-shaped pH-rate profiles in alpha-chymotrypsin-catalyzed hydrolyses.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 85, 1963, DC US, pages 358 - 359, XP002244404
CHEMICAL ABSTRACTS, vol. 86, no. 11, 1977, Columbus, Ohio, US; abstract no. 72508v, ZUKOWSKI, EDWARD ET AL.: "Modification of 6-aminopenicillanic acid derivatives." page 603; column 2; XP002244405
BLODGETT J K ET AL: "SPECIFIC CLEAVAGE OF PEPTIDES CONTAINING AN ASPARTIC ACID (BETA-HYDROXAMIC ACID) RESIDUE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 107, no. 14, 1985, pages 4305 - 4313, XP002020788, ISSN: 0002-7863
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002244406
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002244407
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002244408
PATENT ABSTRACTS OF JAPAN vol. 007, no. 201 (C - 184) 6 September 1983 (1983-09-06)
BYOUNG-MOG KWON ET AL.: "Photooxygenation of ascorbic acid derivatives and model compounds", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 111, no. 5, 1989, DC US, pages 1854 - 1860, XP002256128
CHEMICAL ABSTRACTS, vol. 54, no. 11, 10 June 1960, Columbus, Ohio, US; abstract no. 10856d, RUDOLF W. BALSIGER ETAL.: "Synthesis of potential anticancer agents." page 10855; column 2; XP002256130
TAKAYAMA SHUICHI ET AL: "Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferase: donar sugar-nucleotide based approach", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 7, February 1999 (1999-02-01), pages 401 - 409, XP002963943, ISSN: 0968-0896
ROBERT S. WEHBIE ET AL.: "Rat liver-gamma-butyrobetaine hydroxylase catalyzed reaction", BIOCHEMISTRY., vol. 27, no. 6, 1988, EASTON, PA US, pages 2222 - 2228, XP002256129
Download PDF: