Title:
HIGH AFFINITY MAGE-A1-SPECIFIC TCRS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/170338
Kind Code:
A3
Abstract:
The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human MAGE-A1 epitopes), T cells expressing such high affinity antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
Inventors:
CHAPUIS AUDE (US)
SCHMITT THOMAS (US)
MCAFEE MEGAN (US)
SCHMITT THOMAS (US)
MCAFEE MEGAN (US)
Application Number:
PCT/US2018/022759
Publication Date:
November 21, 2019
Filing Date:
March 15, 2018
Export Citation:
Assignee:
HUTCHINSON FRED CANCER RES (US)
International Classes:
A61K39/395; C07K16/30
Foreign References:
| US20150353622A1 | 2015-12-10 | |||
| CN102295702A | 2011-12-28 | |||
| US20150292034A1 | 2015-10-15 | |||
| CN106749620A | 2017-05-31 |
Other References:
DATABASE Genbank [online] 16 January 2015 (2015-01-16), "Treponema azotonutricium ZAS-9, complete genome", Database accession no. CP001841
DATABASE Genbank [online] 19 October 2012 (2012-10-19), "Hordeum vulgare subsp. vulgare cv. Morex GSS, clone HVVMRXALLMA0066A09, genomic survey sequence", Database accession no. HF380962
DATABASE Genbank [online] 19 October 2012 (2012-10-19), "Hordeum vulgare subsp. vulgare cv. Morex GSS, clone HVVMRXALLMA0066A09, genomic survey sequence", Database accession no. HF380962
Attorney, Agent or Firm:
MORGAN, John, A. et al. (US)
Download PDF:
Previous Patent: DROP-STITCH FOR AN INFLATABLE DEVICE
Next Patent: MONO TO POLY AXIAL UNIVERSAL PEDICLE SCREW AND METHOD OF USING THE SAME
Next Patent: MONO TO POLY AXIAL UNIVERSAL PEDICLE SCREW AND METHOD OF USING THE SAME