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Title:
HIGH-AFFINITY SOLUBLE PD-1 MOLECULE
Document Type and Number:
WIPO Patent Application WO/2018/077189
Kind Code:
A1
Abstract:
Provided is a high-affinity soluble PD-1 molecule. In particular, provided is a programmed death receptor PD-1 molecule wherein the mutation occurs on the basis of the wild-type PD-1 molecule. In addition, the affinity between the PD-1 molecule and the ligand PDL-1 molecule thereof is at least twice the affinity between the wild-type PD-1 molecule and the wild-type PDL-1 molecule. Moreover, the PD-1 molecule in the present invention can effectively improve the killing capability of lymphocytes. Furthermore, also provided are a nucleic acid encoding the PD-1 molecule of the present invention and a complex of the PD-1 molecule of the present invention. The PD-1 molecule of the present invention can be used alone, and can also be used in combination with other molecules.

Inventors:
LI YI (CN)
LI YANYAN (CN)
Application Number:
PCT/CN2017/107659
Publication Date:
May 03, 2018
Filing Date:
October 25, 2017
Export Citation:
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Assignee:
GUANGDONG XIANGXUE LIFE SCIENCES LTD (CN)
International Classes:
C07K14/705; A61K38/17; A61P35/00; C07K19/00; C12N15/12; C12N15/62
Domestic Patent References:
WO2016023001A12016-02-11
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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