Title:
HIGH-AFFINITY T-CELL RECEPTOR FOR ANTIGEN SSX2
Document Type and Number:
WIPO Patent Application WO/2023/005859
Kind Code:
A1
Abstract:
A T cell receptor (TCR), having the characteristic of binding a AQIPEKIQK (SEQ ID NO: 34)-HLAA 1101 complex. Disclosed are a multivalent TCR complex, a nucleic acid molecule encoding the TCR, a vector containing nucleic acids, a cell expressing the TCR and a pharmaceutical composition containing same, which may be used for diagnosing, treating and preventing SSX2 positive diseases. Also disclosed is a method for preparing the TCR.
More Like This:
Inventors:
HUANG JINHUA (CN)
LIU MIN (CN)
ZHANG TINGTING (CN)
WENG ZHIMING (CN)
CHEN JIANJUN (CN)
LIU MIN (CN)
ZHANG TINGTING (CN)
WENG ZHIMING (CN)
CHEN JIANJUN (CN)
Application Number:
PCT/CN2022/107561
Publication Date:
February 02, 2023
Filing Date:
July 25, 2022
Export Citation:
Assignee:
XLIFESC LTD (CN)
International Classes:
C07K14/725; A61K35/17; A61K38/17; A61P35/00; C07K19/00; C12N5/10; C12N15/12; C12N15/85
Foreign References:
| CN111954679A | 2020-11-17 | |||
| CN1691964A | 2005-11-02 | |||
| CN112512538A | 2021-03-16 | |||
| CN106336457A | 2017-01-18 | |||
| CN112409474A | 2021-02-26 |
Other References:
CARSTEN LINNEMANN, BIANCA HEEMSKERK, PIA KVISTBORG, ROELOF J C KLUIN, DMITRIY A BOLOTIN, XIAOJING CHEN, KASPAR BRESSER, MARJA NIEU: "High-throughput identification of antigen-specific TCRs by TCR gene capture", NATURE MEDICINE, NATURE PUB. CO., vol. 19, no. 11, pages 1534 - 1541, XP055190765, ISSN: 10788956, DOI: 10.1038/nm.3359
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
Download PDF: