Title:
HIGH-AFFINITY TCR FOR AFP RECOGNITION
Document Type and Number:
WIPO Patent Application WO/2020/098717
Kind Code:
A1
Abstract:
Provided in the present invention is a T-cell receptor (TCR) having the characteristic of binding a FMNKFIYEI-HLA A0201 complex; and the binding affinity of the TCR to the FMNKFIYEI-HLA A0201 complex is at least 5 times that of a wild-type TCR to the FMNKFIYEI-HLA A0201 complex. Further provided in the present invention is a fusion molecule of the TCR with a therapeutic agent. The TCR can be used alone or in combination with the therapeutic agent, so as to target a tumor cell presenting the FMNKFIYEI-HLA A0201 complex.
Inventors:
LI YI (CN)
CHEN LIANG (CN)
CHEN LIANG (CN)
Application Number:
PCT/CN2019/118139
Publication Date:
May 22, 2020
Filing Date:
November 13, 2019
Export Citation:
Assignee:
GUANGDONG XIANGXUE LIFE SCIENCES LTD (CN)
International Classes:
C07K14/725; A61K35/17; A61K38/17; A61P35/00; C12N5/10; C12N15/12; C12N15/63
Domestic Patent References:
| WO2014206304A1 | 2014-12-31 |
Foreign References:
| CN104087592A | 2014-10-08 | |||
| CN105408353A | 2016-03-16 | |||
| CN107106671A | 2017-08-29 | |||
| CN110343166A | 2019-10-18 | |||
| CN2015093806W | 2015-11-04 | |||
| CN2016077680W | 2016-03-29 |
Other References:
BUTTERFIELD ET AL., J IMMUNOL., vol. 166, no. 8, 15 April 2001 (2001-04-15), pages 5300 - 8
SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PUBLISHING COMPANY
RASHTCHIAN, CURR OPIN BIOTECHNOL, vol. 6, no. 1, 1995, pages 30 - 6
LI ET AL., NATURE BIOTECH, vol. 23, no. 3, 2005, pages 349 - 354
KOPPE ET AL., CANCER METASTASIS REVIEWS, vol. 24, 2005, pages 539
CHAUDHARY ET AL., NATURE, vol. 339, 1989, pages 394
EPEL ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 51, 2002, pages 565
GILLIES ET AL., NATIONAL ACADEMY OF SCIENCES (PNAS, vol. 89, 1992, pages 1428
CARD ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 53, 2004, pages 345
HALIN ET AL., CANCER RESEARCH, vol. 63, 2003, pages 3202
MOSQUERA ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 174, 2005, pages 4381
ZHU ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 62, 1995, pages 319
LAPOTKO ET AL., CANCER LETTERS, vol. 239, 2005, pages 36
HUANG ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 2115
PENG ET AL., GENE THERAPY, vol. 11, 2004, pages 1234
MAMOT ET AL., CANCER RESEARCH, vol. 65, 2005, pages 11631
ROBBINS ET AL., J. IMMUNOL., vol. 180, 2008, pages 6116 - 6131
ROSENBERG ET AL., NAT REV CANCER, vol. 8, no. 4, 2008, pages 299 - 308
"Remington's Pharmaceutical Sciences", 1991, MACK PUB. CO.
SAMBROOKRUSSELL: "Molecular Cloning a Laboratory Manual"
See also references of EP 3892629A4
SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PUBLISHING COMPANY
RASHTCHIAN, CURR OPIN BIOTECHNOL, vol. 6, no. 1, 1995, pages 30 - 6
LI ET AL., NATURE BIOTECH, vol. 23, no. 3, 2005, pages 349 - 354
KOPPE ET AL., CANCER METASTASIS REVIEWS, vol. 24, 2005, pages 539
CHAUDHARY ET AL., NATURE, vol. 339, 1989, pages 394
EPEL ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 51, 2002, pages 565
GILLIES ET AL., NATIONAL ACADEMY OF SCIENCES (PNAS, vol. 89, 1992, pages 1428
CARD ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 53, 2004, pages 345
HALIN ET AL., CANCER RESEARCH, vol. 63, 2003, pages 3202
MOSQUERA ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 174, 2005, pages 4381
ZHU ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 62, 1995, pages 319
LAPOTKO ET AL., CANCER LETTERS, vol. 239, 2005, pages 36
HUANG ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 2115
PENG ET AL., GENE THERAPY, vol. 11, 2004, pages 1234
MAMOT ET AL., CANCER RESEARCH, vol. 65, 2005, pages 11631
ROBBINS ET AL., J. IMMUNOL., vol. 180, 2008, pages 6116 - 6131
ROSENBERG ET AL., NAT REV CANCER, vol. 8, no. 4, 2008, pages 299 - 308
"Remington's Pharmaceutical Sciences", 1991, MACK PUB. CO.
SAMBROOKRUSSELL: "Molecular Cloning a Laboratory Manual"
See also references of EP 3892629A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: INHIBITOR OF BRUTON TYROSINE KINASE
Next Patent: APPARATUS AND METHOD FOR DISCONTINUOUS RECEPTION OF SAME
Next Patent: APPARATUS AND METHOD FOR DISCONTINUOUS RECEPTION OF SAME