Title:
HIGH AVIDITY BINDING MOLECULES RECOGNIZING MAGE-A1
Document Type and Number:
WIPO Patent Application WO/2014/118236
Kind Code:
A8
Abstract:
The present invention pertains to novel high avidity antigen recognizing constructs, such as antibodies or T cell receptors, which specifically bind to the melanoma associated antigen (MAGE) A1. The constructs of the invention are particularly useful for the diagnosis, prevention or therapy of tumorous diseases which are characterized by the specific expression of the MAGE-A1 antigen. Furthermore provided are nucleic acids, vectors and host cells - such as CD4 or CD8 positive T cells - which encode, comprise or present the antigen recognizing constructs of the invention. The invention thus provides new means for immune therapy, specifically adoptive T cell therapy, for treating cancer.
Inventors:
BLANKENSTEIN THOMAS (DE)
OBENAUS MATTHIAS (DE)
LEITAO CATARINA (PT)
OBENAUS MATTHIAS (DE)
LEITAO CATARINA (PT)
Application Number:
PCT/EP2014/051726
Publication Date:
December 18, 2014
Filing Date:
January 29, 2014
Export Citation:
Assignee:
MAX DELBRÜCK CT FÜR MOLEKULARE MEDIZIN MDC BERLIN BUCH (DE)
International Classes:
C07K14/725; A61K39/395; A61P35/00; C07K16/30; C12N15/12; C12N15/13
Attorney, Agent or Firm:
BOEHMERT & BOEHMERT ANWALTSPARTNERSCHAFT MBB PATENTANWÄLTE RECHTSANWÄLTE (Pettenkoferstrasse 20 - 22, Munich, DE)
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