Title:
HIGH AVIDITY WT1 T CELL RECEPTORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/185796
Kind Code:
A9
Abstract:
The present disclosure provides T cell receptors (TCRs) and related binding proteins with high functional avidity against tumor associated antigen p37 from Wilms tumor protein 1 (WT1), T cells expressing such high affinity WT1 specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress WT1 and/or produce the p37 antigen, such as in cancer.
Inventors:
SCHMITT THOMAS M (US)
CHAPUIS AUDE G (US)
GREENBERG PHILIP D (US)
CHAPUIS AUDE G (US)
GREENBERG PHILIP D (US)
Application Number:
PCT/US2020/021916
Publication Date:
October 15, 2020
Filing Date:
March 10, 2020
Export Citation:
Assignee:
HUTCHINSON FRED CANCER RES (US)
International Classes:
C07K14/725; A61K35/17; C12N5/0783
Attorney, Agent or Firm:
MORGAN, John, A. et al. (US)
Download PDF: