Title:
HIGH EFFICIENCY APTAMER COMPLEX COMPRISING BRANCHED DNA AND APTAMER, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/189979
Kind Code:
A1
Abstract:
The present invention relates to a high efficiency aptamer complex comprising branched DNA and an aptamer, and a pharmaceutical use thereof. More specifically, the aptamer complex of the present invention is a high efficiency aptamer complex in which Y-shape DNA is included as branched DNA and vascular endothelial growth factor (VEGF) is used as a target molecule. An aptamer complex and a pharmaceutical composition comprising same as an active ingredient, of the present invention, have target molecule binding efficiency that is more remarkable than that of a conventional aptamer, and thus are expected to be widely used in the medical field.
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Inventors:
KIM WON JONG (KR)
LEE JI HYUN (KR)
LEE JI HYUN (KR)
Application Number:
PCT/KR2018/004326
Publication Date:
October 03, 2019
Filing Date:
April 13, 2018
Export Citation:
Assignee:
POSTECH ACAD IND FOUND (KR)
International Classes:
C12N15/115; A61K31/7088; A61K47/54; A61P35/00; G01N33/574
Foreign References:
| KR20140091750A | 2014-07-22 | |||
| KR20160101260A | 2016-08-25 |
Other References:
CANSIZ, SENA: "DNA aptamer based nanodrugs: molecular engineering for efficiency", CHEMISTRY - AN ASIAN JOURNAL, vol. 10, 2015, pages 2084 - 2094, XP055640525
MENG, HONG-MIN: "Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy", CHEMICAL SOCIETY REVIEWS, vol. 45, no. 9, 2016, pages 2583 - 2602, XP055640527
WU, CUICHEN: "Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, 2013, pages 18644 - 18650, XP055235740, doi:10.1021/ja4094617
PARK, KYUNG SOO: "Predictive evaluation for the preparation of a synthetic Y-shaped DNA nanostructure", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 19, 2014, pages 262 - 268, XP055640529
MENG, HONG-MIN: "Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy", CHEMICAL SOCIETY REVIEWS, vol. 45, no. 9, 2016, pages 2583 - 2602, XP055640527
WU, CUICHEN: "Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, 2013, pages 18644 - 18650, XP055235740, doi:10.1021/ja4094617
PARK, KYUNG SOO: "Predictive evaluation for the preparation of a synthetic Y-shaped DNA nanostructure", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 19, 2014, pages 262 - 268, XP055640529
Attorney, Agent or Firm:
KIM, Sung Ho et al. (KR)
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