Title:
HIGH-EFFICIENCY LOW-TOXICITY ANTI-CANCER COMPOUND SYNTHESIZED BY AUTOCATALYSIS IN CELLS AND LIVING BODIES AND SYNTHESIS METHOD FOR ANTI-CANCER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/139395
Kind Code:
A1
Abstract:
Disclosed is a high-efficiency low-toxicity anti-cancer compound synthesized by autocatalysis in cells and living bodies. The anti-cancer compound is prepared by means of chemical synthesis of a metal complex precursor and an organic active molecule precursor outside the cells or synthesis of the metal complex precursor and the organic active molecule precursor in the cells by means of a bioorthogonal reaction. The metal complex is a platinum, ruthenium, iridium or osmium metal complex, and the organic active molecule means small organic molecules having certain biological activities, for example, the small organic molecules having biological activities such as anti-inflammation, anti-bacteria, anti-angiogenesis, and anti-cancer. The organic active molecule precursor is an organic active molecule subjected to chemical modification, and the organic active molecule is one of rhein acid, oleanolic acid, ursolic acid, naphthalimide, cumarin acid, anthracene-9-carboxylic acid or indometacin. Also disclosed is a synthesis method for the anti-cancer compound. The anti-cancer compound in the present invention shows a good anti-tumor effect by being synthesized by means of either an extracellular reaction or an intracellular reaction.
Inventors:
LIU HONGKE (CN)
XUE XULING (CN)
TAO QIN (CN)
LV MENGDI (CN)
CHEN JUN (CN)
QIAN XIAOTING (CN)
XUE XULING (CN)
TAO QIN (CN)
LV MENGDI (CN)
CHEN JUN (CN)
QIAN XIAOTING (CN)
Application Number:
PCT/CN2020/128238
Publication Date:
July 15, 2021
Filing Date:
November 12, 2020
Export Citation:
Assignee:
UNIV NANJING (CN)
International Classes:
C07F15/00; A61P35/00; C07F17/02; C07J63/00; C12P17/16; C12P33/20
Foreign References:
| CN111171080A | 2020-05-19 | |||
| CN105713047A | 2016-06-29 | |||
| CN109824735A | 2019-05-31 | |||
| CN108358973A | 2018-08-03 | |||
| CN108530343A | 2018-09-14 | |||
| CN107619425A | 2018-01-23 | |||
| CN101289467A | 2008-10-22 | |||
| CN108727437A | 2018-11-02 |
Other References:
PĂUNESCU EMILIA, MCARTHUR SARAH, SOUDANI MYLÈNE, SCOPELLITI ROSARIO, DYSON PAUL J.: "Nonsteroidal Anti-inflammatory—Organometallic Anticancer Compounds", INORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON , US, vol. 55, no. 4, 15 February 2016 (2016-02-15), Easton , US, pages 1788 - 1808, XP055827448, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.5b02690
TADIĆ ANA, POLJAREVIĆ JELENA, KRSTIĆ MILENA, KAJZERBERGER MARIJANA, ARANĐELOVIĆ SANDRA, RADULOVIĆ SINIŠA, KAKOULIDOU CHRISOULA, PA: "Ruthenium–arene complexes with NSAIDs: synthesis, characterization and bioactivity", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 42, no. 4, 1 January 2018 (2018-01-01), GB, pages 3001 - 3019, XP055827449, ISSN: 1144-0546, DOI: 10.1039/C7NJ04416J
ANDRADE GABRIEL A., PISTNER ALLEN J., YAP GLENN P. A., LUTTERMAN DANIEL A., ROSENTHAL JOEL: "Photocatalytic Conversion of CO 2 to CO Using Rhenium Bipyridine Platforms Containing Ancillary Phenyl or BODIPY Moieties", ACS CATALYSIS, AMERICAN CHEMICAL SOCIETY, US, vol. 3, no. 8, 2 August 2013 (2013-08-02), US, pages 1685 - 1692, XP055827450, ISSN: 2155-5435, DOI: 10.1021/cs400332y
TADIĆ ANA, POLJAREVIĆ JELENA, KRSTIĆ MILENA, KAJZERBERGER MARIJANA, ARANĐELOVIĆ SANDRA, RADULOVIĆ SINIŠA, KAKOULIDOU CHRISOULA, PA: "Ruthenium–arene complexes with NSAIDs: synthesis, characterization and bioactivity", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 42, no. 4, 1 January 2018 (2018-01-01), GB, pages 3001 - 3019, XP055827449, ISSN: 1144-0546, DOI: 10.1039/C7NJ04416J
ANDRADE GABRIEL A., PISTNER ALLEN J., YAP GLENN P. A., LUTTERMAN DANIEL A., ROSENTHAL JOEL: "Photocatalytic Conversion of CO 2 to CO Using Rhenium Bipyridine Platforms Containing Ancillary Phenyl or BODIPY Moieties", ACS CATALYSIS, AMERICAN CHEMICAL SOCIETY, US, vol. 3, no. 8, 2 August 2013 (2013-08-02), US, pages 1685 - 1692, XP055827450, ISSN: 2155-5435, DOI: 10.1021/cs400332y
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
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