Title:
HIGH-SENSITIVITY NANOPLASMONIC BIOSENSOR FOR DETECTING AUTOPHAGY MARKERS, MANUFACTURING METHOD THEREFOR, AND AUTOPHAGY MARKER DETECTION METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/225255
Kind Code:
A1
Abstract:
The present invention relates to a high-sensitivity nanoplasmonic biosensor for detecting autophagy markers by plasmon resonance effect, a manufacturing method therefor, and an autophagy marker detection method using same. The nanoplasmonic biosensor according to the present invention can detect LC3, which is an autophagy marker, by using a plasmon resonance effect even without an additional marker, can perform detection at a low sensitivity and in a wide concentration range, and can quantify the concentration of a target protein on the basis thereof, and thus can be used for effectively measuring autophagy markers. Therefore, the nanoplasmonic biosensor according to the present invention can be variously used for: the detection of a complex mixture; the early detection of cancer; the early prevention of infections, neurological disorders and the like; and the like.
Inventors:
SIM SANG JUN (KR)
LEE JONG UK (KR)
CHOI YOUNG JAE (KR)
LEE JONG UK (KR)
CHOI YOUNG JAE (KR)
Application Number:
PCT/KR2022/005390
Publication Date:
October 27, 2022
Filing Date:
April 14, 2022
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
G01N21/552; G01N21/59; G01N33/543; G01N33/577
Foreign References:
| KR20160128654A | 2016-11-08 | |||
| KR20160128213A | 2016-11-07 | |||
| KR20130001886A | 2013-01-07 | |||
| KR20140108810A | 2014-09-15 |
Other References:
SHUNSUKE KIMURA, TAKESHI NODA, TAMOTSU YOSHIMORI: "Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3", AUTOPHAGY, LANDES BIOSCIENCE, US, vol. 3, no. 5, 20 September 2007 (2007-09-20), US , pages 452 - 460, XP055557658, ISSN: 1554-8627, DOI: 10.4161/auto.4451
Attorney, Agent or Firm:
JUNG, Eun Youl et al. (KR)
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