HIGH THROUGHPUT ASSAY SYSTEM - HIGH THROUGHPUT GENOMICS INC

Title:

HIGH THROUGHPUT ASSAY SYSTEM

Document Type and Number:

WIPO Patent Application WO2003002750

Kind Code:

A3

Abstract:

The present invention relates to compositions, apparatus and methods useful for concurrently performing multiple, high throughput, biological or chemical assays, using repeated arrays of probes. A combination of the invention comprises a surface, which comprises a plurality of test regions, at least two of which, and in a preferred embodiment, at least twenty of which, are substantially identical, wherein each of the test regions comprises an array of generic anchor molecules. The anchors are associated with bifunctional linker molecules, each containing a portion which is specific for at least one of the anchors and a portion which is a probe specific for a target of interest. The resulting array of probes is used to analyze the presence or test the activity of one or more target molecules which specifically interact with the probes. In a preferred embodiment, a sample to be tested is subjected to a nuclease protection procedure before it is contacted with a combination of the invention.

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Inventors:

KRIS RICHARD M (US)
FELDER STEPHEN (US)

Application Number:

PCT/US2002/020039

Publication Date:

December 11, 2003

Filing Date:

June 26, 2002

Export Citation:

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Assignee:

HIGH THROUGHPUT GENOMICS INC (US)
KRIS RICHARD M (US)
FELDER STEPHEN (US)

International Classes:

G01N33/53; C12N15/09; C12Q1/42; C12Q1/68; G01N21/76; G01N37/00; G16B25/00; C40B40/06; C40B60/14; C40B70/00; (IPC1-7): C12Q1/68; C12P19/34; C07H21/02

Foreign References:

US6238869B1	2001-05-29
US6200781B1	2001-03-13

Other References: