Title:
HIGH THROUGHPUT METHOD OF PERSONALIZED TARGET ENRICHMENT PANEL ASSEMBLY
Document Type and Number:
WIPO Patent Application WO/2019/161242
Kind Code:
A3
Abstract:
Disclosed herein are methods of generating a subpool of oligonucleotides from a larger pool of oligonucleotides. A subpool of oligonucleotides can contain a portion of a gene of interest, and can be generated on a subject by subject basis on demand. Also disclosed herein are methods of processing a subpool of oligonucleotides to generate probes for sequencing. Also disclosed herein are systems and methods for using subpools of oligonucleotides generated from a larger pool for high-throughput sequencing.
Inventors:
CULVER BRADY PATRICK (US)
BANOS MICHAEL (US)
BANOS MICHAEL (US)
Application Number:
PCT/US2019/018271
Publication Date:
October 17, 2019
Filing Date:
February 15, 2019
Export Citation:
Assignee:
NOVA BIOLABS INC (US)
International Classes:
C12Q1/68
Other References:
PLATT ET AL.: "Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes", J MOL DIAGN., vol. 17, no. 6, November 2015 (2015-11-01), pages 661 - 668, XP055644620
JENNINGS ET AL.: "Guidelines for Validation of Next-Generation Sequencing-Based Oncology Panels. A Joint Consensus Recommendation of the Association for Molecular Pathology and College of American Pathologists", THE JOURNAL OF MOLECULAR DIAGNOSTICS, vol. 19, no. 3, May 2017 (2017-05-01), pages 341 - 365, XP055644626
COUCH ET AL.: "Two decades after BRCA: setting paradigms in personalized cancer care and prevention", SCIENCE, vol. 343, no. 6178, 28 March 2014 (2014-03-28), pages 1466 - 1470, XP055644635
MEDEIROS ET AL.: "Isocitrate dehydrogenase mutations in myeloid malignancies", LEUKEMIA, vol. 31, no. 2, 2017, pages 272 - 281, XP055644636
JENNINGS ET AL.: "Guidelines for Validation of Next-Generation Sequencing-Based Oncology Panels. A Joint Consensus Recommendation of the Association for Molecular Pathology and College of American Pathologists", THE JOURNAL OF MOLECULAR DIAGNOSTICS, vol. 19, no. 3, May 2017 (2017-05-01), pages 341 - 365, XP055644626
COUCH ET AL.: "Two decades after BRCA: setting paradigms in personalized cancer care and prevention", SCIENCE, vol. 343, no. 6178, 28 March 2014 (2014-03-28), pages 1466 - 1470, XP055644635
MEDEIROS ET AL.: "Isocitrate dehydrogenase mutations in myeloid malignancies", LEUKEMIA, vol. 31, no. 2, 2017, pages 272 - 281, XP055644636
Attorney, Agent or Firm:
MATA, David G. (US)
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