Title:
HIGH-THROUGHPUT STEM CELL ASSAY OF HEMATOPOIETIC STEM AND PROGENITOR CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2003004995
Kind Code:
A3
Abstract:
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the growth of hematopoietic stem and progenitor cells and for identifying subpopulations thereof that are suitable for transplantation. The assay of the present invention is particularly useful for quality control and monitoring of the growth potential in the stem cell transplant setting and would provide improved control over the reconstitution phase of transplanted cells.
Inventors:
RICH IVAN N (US)
Application Number:
PCT/US2002/002458
Publication Date:
May 22, 2003
Filing Date:
January 29, 2002
Export Citation:
Assignee:
RICH IVAN N (US)
International Classes:
C12N5/02; C12Q1/02; C12Q1/66; G01N33/50; (IPC1-7): C12N5/00; C12N5/02
Domestic Patent References:
| WO1992013063A1 | 1992-08-06 |
Other References:
HOROWITZ D. ET AL.: "Colorimetric determination of inhibition of hematopoietic progenitor cells in soft agar", J. OF IMMUNOLOGICAL METHODS, vol. 244, 2000, pages 49 - 58, XP004218445
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