Title:
HIGH-YIELD EUROTIUM CRISTATUM STRAIN CONTAINING DIKETOPIPERAZINE DIMER, AND METHOD FOR SEPARATING AND PURIFYING DIKETOPIPERAZINE DIMER THEREFROM
Document Type and Number:
WIPO Patent Application WO/2021/143833
Kind Code:
A1
Abstract:
Provided are a high-yield eurotium cristatum strain containing a diketopiperazine dimer, a method for separating and purifying the diketopiperazine dimer therefrom, and a use of a diketopiperazine dimer in the preparation of a hypoglycemic drug.
Inventors:
FAN DAIDI (CN)
ZHU CHENHUI (CN)
LIU GANG (CN)
HUI JUNFENG (CN)
ZHANG HUI (CN)
ZHU CHENHUI (CN)
LIU GANG (CN)
HUI JUNFENG (CN)
ZHANG HUI (CN)
Application Number:
PCT/CN2021/072126
Publication Date:
July 22, 2021
Filing Date:
January 15, 2021
Export Citation:
Assignee:
UNIV NORTHWEST (CN)
International Classes:
C12N1/14; C07D519/00; C12N3/00; C12P17/18; C12R1/645
Foreign References:
| CN111235036A | 2020-06-05 | |||
| CN108057154A | 2018-05-22 | |||
| CN101027082A | 2007-08-29 | |||
| CN101151047A | 2008-03-26 |
Other References:
ZHANG HUI; HUI JUNFENG; YANG JING; DENG JIANJUN; FAN DAIDI: "Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 887, 16 September 2020 (2020-09-16), pages 1 - 12, XP086323314, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2020.173557
GOMES NELSON M., DETHOUP TIDA, SINGBURAUDOM NARONG, GALES LUÍS, SILVA ARTUR M.S., KIJJOA ANAKE: "Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum", PHYTOCHEMISTRY LETTERS, vol. 5, no. 4, 1 December 2012 (2012-12-01), pages 717 - 720, XP055830032, ISSN: 1874-3900, DOI: 10.1016/j.phytol.2012.07.010
LIU YINGHUI;GAO LI: "Research Progress on the Secondary Products of Eurotium", JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 36, no. 9, 15 September 2017 (2017-09-15), pages 542 - 547, XP055830033, DOI: 10.13506/j.cnki.jpr.2017.09.013
GOMES NELSON M., DETHOUP TIDA, SINGBURAUDOM NARONG, GALES LUÍS, SILVA ARTUR M.S., KIJJOA ANAKE: "Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum", PHYTOCHEMISTRY LETTERS, vol. 5, no. 4, 1 December 2012 (2012-12-01), pages 717 - 720, XP055830032, ISSN: 1874-3900, DOI: 10.1016/j.phytol.2012.07.010
LIU YINGHUI;GAO LI: "Research Progress on the Secondary Products of Eurotium", JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 36, no. 9, 15 September 2017 (2017-09-15), pages 542 - 547, XP055830033, DOI: 10.13506/j.cnki.jpr.2017.09.013
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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