Title:
A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES
Document Type and Number:
WIPO Patent Application WO/2015/042201
Kind Code:
A3
Abstract:
Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear -alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 -hydroxyketone intermediate through an aldol addition; and b) converting the CN+3 -hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
Inventors:
CHOKHAWALA HARSHAL (US)
Application Number:
PCT/US2014/056175
Publication Date:
June 04, 2015
Filing Date:
September 17, 2014
Export Citation:
Assignee:
ZYMOCHEM INC (US)
CHOKHAWALA HARSHAL (US)
CHOKHAWALA HARSHAL (US)
International Classes:
C12P7/40
Foreign References:
| US20120282661A1 | 2012-11-08 | |||
| US20110195466A1 | 2011-08-11 | |||
| US20110177571A1 | 2011-07-21 | |||
| US20110236938A1 | 2011-09-29 | |||
| US20060252135A1 | 2006-11-09 |
Other References:
HARA ET AL.: "Characterization of the 4-Carboxy-4-Hydroxy-2-Oxoadipate Aldolase Gene and Operon Structure of the Protocatechuate 4,5-Cleavage Pathway Genes in Sphingomonas paucimobilis SYK-6", JOURNAL OF BACTERIOLOGY, January 2003 (2003-01-01), pages 41 - 50, XP055326681
EHRLICH ET AL.: "An acid phosphatase from Aspergillus ficuum has homology to Penicillium chrysogenum PhoA", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 204, no. 1, 1994, pages 63 - 68, XP024765853
EHRLICH ET AL.: "An acid phosphatase from Aspergillus ficuum has homology to Penicillium chrysogenum PhoA", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 204, no. 1, 1994, pages 63 - 68, XP024765853
Attorney, Agent or Firm:
KONSKI, Antoinette F. et al. (3000 K Street N.W. Suite 60, Washington District of Columbia, US)
Download PDF:
Previous Patent: BIOMOLECULE SEQUENCING DEVICES, SYSTEMS AND METHODS
Next Patent: CHLOROTOXIN CONJUGATES AND METHODS OF USE THEREOF
Next Patent: CHLOROTOXIN CONJUGATES AND METHODS OF USE THEREOF