HIGHLY CONCENTRATED POURABLE AQUEOUS SOLUTIONS OF POTASSIUM IBUPROFEN, THEIR PREPARATION AND THEIR USES

Title:

HIGHLY CONCENTRATED POURABLE AQUEOUS SOLUTIONS OF POTASSIUM IBUPROFEN, THEIR PREPARATION AND THEIR USES

Document Type and Number:

WIPO Patent Application WO2005065665

Kind Code:

A3

Abstract:

Concentrated pourable potassium ibuprofen liquid compositions and their preparation are described. They are comprised of (i) potassium ibuprofen, (ii) water; and (iii) methanol, ethanol, 1-propanol, 2-propanol, 1,1-dimethylethanol, or a mixture of any two or more of them. The amount of dissolved potassium ibuprofen in the composition is in the range of about 60 to about 90 wt%. These compositions are suitable for use in the preparation of pharmaceutical dosage form such as liquid-filled soft gelatin capsules, syrups, elixirs, suspensions; solid dosage forms such as tablets or caplets; and topically-applied products such as lotions, creams or ointments.

Inventors:

HU PATRICK C (US)
LAMBETH GREGORY H (US)
MALCOLM ARCELIO J (US)

Application Number:

PCT/US2004/041584

Publication Date:

November 24, 2005

Filing Date:

December 13, 2004

Export Citation:

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Assignee:

ALBEMARLE CORP (US)
HU PATRICK C (US)
LAMBETH GREGORY H (US)
MALCOLM ARCELIO J (US)

International Classes:

A61K9/48; A61K31/19; A61K31/192; (IPC1-7): A61K9/48; A61K31/19

Domestic Patent References:

WO2002076398A2	2002-10-03
WO2002017855A2	2002-03-07
WO1994014423A1	1994-07-07
WO1989009053A1	1989-10-05
WO1993011753A1	1993-06-24

Foreign References:

US5071643A

1991-12-10

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