Title:
HIGHLY FUNCTIONAL ANTIBODY LIBRARIES
Document Type and Number:
WIPO Patent Application WO/2019/099454
Kind Code:
A3
Abstract:
The present invention relates to a method for the generation of antibody libraries of improved functionality and uses of thereof by combining a library of antibodies pre-selected for functional properties relevant to developability, such as for example improved thermal stability, with a library of CDR-H3 fragments.
More Like This:
Inventors:
VALADON PHILIPPE (US)
ALMAGRO JUAN (US)
ALMAGRO JUAN (US)
Application Number:
PCT/US2018/060933
Publication Date:
July 04, 2019
Filing Date:
November 14, 2018
Export Citation:
Assignee:
VALADON PHILIPPE (US)
ALMAGRO JUAN CARLOS (US)
ALMAGRO JUAN CARLOS (US)
International Classes:
C07K16/00; C07K16/18; C07K16/24; C12N15/10; C40B30/04; C40B50/06
Domestic Patent References:
| WO2009132287A2 | 2009-10-29 | |||
| WO2009036379A2 | 2009-03-19 | |||
| WO2007056441A2 | 2007-05-18 | |||
| WO2007134050A2 | 2007-11-22 |
Foreign References:
| EP2728000A1 | 2014-05-07 |
Other References:
DAE YOUNG KIM ET AL: "Antibody light chain variable domains and their biophysically improved versions for human immunotherapy", MABS, vol. 6, no. 1, 20 January 2014 (2014-01-20), US, pages 219 - 235, XP055394573, ISSN: 1942-0870, DOI: 10.4161/mabs.26844
LAKHRIF ZINEB ET AL: "A method to confer Protein L binding ability to any antibody fragment.", MABS 2016, vol. 8, no. 2, 2016, pages 379 - 388, XP002791446, ISSN: 1942-0870
NELSON RENAE S ET AL: "A universal phage display system for the seamless construction of Fab libraries", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 450, 26 July 2017 (2017-07-26), pages 41 - 49, XP085187524, ISSN: 0022-1759, DOI: 10.1016/J.JIM.2017.07.011
LAKHRIF ZINEB ET AL: "A method to confer Protein L binding ability to any antibody fragment.", MABS 2016, vol. 8, no. 2, 2016, pages 379 - 388, XP002791446, ISSN: 1942-0870
NELSON RENAE S ET AL: "A universal phage display system for the seamless construction of Fab libraries", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 450, 26 July 2017 (2017-07-26), pages 41 - 49, XP085187524, ISSN: 0022-1759, DOI: 10.1016/J.JIM.2017.07.011
Download PDF:
Previous Patent: AN AUTOMATED AERO ALUMINIUM SCRAP SORTING SYSTEM BASED ON LASER INDUCED BREAKDOWN (LIBS) TECHNIQUE
Next Patent: FLASHING LAMP CIRCUIT
Next Patent: FLASHING LAMP CIRCUIT