Title:
HIGHLY GLYCOSYLATED HUMAN BLOOD-CLOTTING FACTOR VIII FUSION PROTEIN, AND MANUFACTURING METHOD AND APPLICATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2018/032637
Kind Code:
A1
Abstract:
A highly glycosylated human blood-clotting factor VIII (FVIII) fusion protein, and a manufacturing method and application of same. The fusion protein comprises, from the N-terminus to the C-terminus, a human (FVIII), a flexible peptide connector, at least one rigid unit of a human chorionic gonadotropin β-subunit carboxyl terminal peptide, and a half-life extending portion (preferentially selected from a human IgG Fc variant). The fusion protein has a similar level of biological activity as a recombinant (FVIII) and an extended in vivo half-life, thereby improving pharmacokinetics and drug efficacy.
Inventors:
LI QIANG (CN)
ZHU WENCHEN (CN)
LI YUANLI (CN)
ZHU CHENGGONG (CN)
GAO YONGJUAN (CN)
REN ZIJIA (CN)
ZHU LUYAN (CN)
SUN NAICHAO (CN)
WANG XIAOSHAN (CN)
LIU BIN (CN)
LI ZHI (CN)
WANG WENWEN (CN)
JIANG MING (CN)
WANG QILEI (CN)
WANG LIRUI (CN)
WANG SHUYA (CN)
ZHU SONGLIN (CN)
GAO JIE (CN)
SU HONGSHENG (CN)
ZHU WENCHEN (CN)
LI YUANLI (CN)
ZHU CHENGGONG (CN)
GAO YONGJUAN (CN)
REN ZIJIA (CN)
ZHU LUYAN (CN)
SUN NAICHAO (CN)
WANG XIAOSHAN (CN)
LIU BIN (CN)
LI ZHI (CN)
WANG WENWEN (CN)
JIANG MING (CN)
WANG QILEI (CN)
WANG LIRUI (CN)
WANG SHUYA (CN)
ZHU SONGLIN (CN)
GAO JIE (CN)
SU HONGSHENG (CN)
Application Number:
PCT/CN2016/106010
Publication Date:
February 22, 2018
Filing Date:
November 16, 2016
Export Citation:
Assignee:
AMPSOURCE BIOPHARMA INC (CN)
FUREN PHARMACEUTICAL GROUP CO LTD (CN)
PHARMAB INC (CN)
KAIFENG PHARMACEUTICAL GROUP CO LTD (CN)
FUREN PHARMACEUTICAL GROUP CO LTD (CN)
PHARMAB INC (CN)
KAIFENG PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07K19/00; A61K38/37; A61P7/04; C12N5/10; C12N15/62; C12N15/85
Foreign References:
| CN106317226A | 2017-01-11 | |||
| CN104519912A | 2015-04-15 | |||
| CN104693270A | 2015-06-10 | |||
| CN104114183A | 2014-10-22 | |||
| CN104903352A | 2015-09-09 | |||
| CN103897064A | 2014-07-02 | |||
| CN104427994A | 2015-03-18 |
Other References:
LI, JIANFANG ET AL.: "Design of Linker Peptides and Its Application in Fusion Protein", JOURNAL OF FOOD SCIENCE AND BIOTECHNOLOGY, vol. 34, no. 11, 30 November 2015 (2015-11-30), pages 1121 - 1127
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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