HIGHLY PERMEATING TERBINAFINE FORMULATION FOR TREATING ONYCHOMYCOSIS

WIPO Patent Application WO/2011/079234

A3

The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomychosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof; a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent; a lower alcohol; and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.

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BUYUKTIMKIN SERVET (US)
BUYUKTIMKIN NADIR (US)
SINGH JAGAT (CA)
NEWSAM JOHN M (US)
KING-SMITH DOMINIC (US)
KISAK EDWARD (US)

PCT/US2010/061940

August 18, 2011

December 22, 2010

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NUVO RES INC (CA)
BUYUKTIMKIN SERVET (US)
BUYUKTIMKIN NADIR (US)
SINGH JAGAT (CA)
NEWSAM JOHN M (US)
KING-SMITH DOMINIC (US)
KISAK EDWARD (US)

A61K9/08; A61K31/137; A61P31/10

WO2011014850A2	2011-02-03
WO2006042059A1	2006-04-20
WO2006131721A2	2006-12-14

ZYLSTRA, Eric J. et al. (Two Embarcadero Center Eighth Floo, San Francisco California, US)

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