Title:
HIGHLY PRODUCTIVE ISOPROPYL ALCOHOL-PRODUCING BACTERIUM
Document Type and Number:
WIPO Patent Application WO/2011/111638
Kind Code:
A1
Abstract:
Disclosed is an Escherichia coli which comprises an isopropyl alcohol production system. The isopropyl alcohol-producing Escherichia coli has at least one enhanced enzymatic activity that is selected from the group consisting of enhanced malate dehydrogenase activity, enhanced NAD(P)+ transhydrogenase (AB-specific) activity and enhanced thiolase activity. Also disclosed is a method for producing isopropyl alcohol, which comprises a process wherein isopropyl alcohol is produced from a plant-derived starting material using the above-described isopropyl alcohol-producing Escherichia coli.
Inventors:
MATSUMOTO YOSHIKO (JP)
HIRANO JUNICHIRO (JP)
MORISHIGE TAKASHI (JP)
SHIRAI TOMOKAZU (JP)
TAKAHASHI HITOSHI (JP)
AMANO KOH (JP)
TAKEBAYASHI NOZOMI (JP)
WADA MITSUFUMI (JP)
SHIMIZU HIROSHI (JP)
FURUSAWA CHIKARA (JP)
HIRASAWA TAKASHI (JP)
HIRANO JUNICHIRO (JP)
MORISHIGE TAKASHI (JP)
SHIRAI TOMOKAZU (JP)
TAKAHASHI HITOSHI (JP)
AMANO KOH (JP)
TAKEBAYASHI NOZOMI (JP)
WADA MITSUFUMI (JP)
SHIMIZU HIROSHI (JP)
FURUSAWA CHIKARA (JP)
HIRASAWA TAKASHI (JP)
Application Number:
PCT/JP2011/055142
Publication Date:
September 15, 2011
Filing Date:
March 04, 2011
Export Citation:
Assignee:
MITSUI CHEMICALS INC (JP)
MATSUMOTO YOSHIKO (JP)
HIRANO JUNICHIRO (JP)
MORISHIGE TAKASHI (JP)
SHIRAI TOMOKAZU (JP)
TAKAHASHI HITOSHI (JP)
AMANO KOH (JP)
TAKEBAYASHI NOZOMI (JP)
WADA MITSUFUMI (JP)
SHIMIZU HIROSHI (JP)
FURUSAWA CHIKARA (JP)
HIRASAWA TAKASHI (JP)
MATSUMOTO YOSHIKO (JP)
HIRANO JUNICHIRO (JP)
MORISHIGE TAKASHI (JP)
SHIRAI TOMOKAZU (JP)
TAKAHASHI HITOSHI (JP)
AMANO KOH (JP)
TAKEBAYASHI NOZOMI (JP)
WADA MITSUFUMI (JP)
SHIMIZU HIROSHI (JP)
FURUSAWA CHIKARA (JP)
HIRASAWA TAKASHI (JP)
International Classes:
C12N1/21; C12P7/04; C12N15/09
Domestic Patent References:
| WO2009008377A1 | 2009-01-15 | |||
| WO2009049274A2 | 2009-04-16 | |||
| WO2009028582A1 | 2009-03-05 | |||
| WO2009008377A1 | 2009-01-15 | |||
| WO2009049274A2 | 2009-04-16 | |||
| WO2009028582A1 | 2009-03-05 | |||
| WO2009103026A1 | 2009-08-20 | |||
| WO2009023493A1 | 2009-02-19 | |||
| WO2009012210A2 | 2009-01-22 | |||
| WO2009111672A1 | 2009-09-11 |
Foreign References:
| JP2009247217A | 2009-10-29 | |||
| JP2010052249A | 2010-03-11 |
Other References:
HANAI, T ET AL.: "Engineered synthetic pathway for isopropanol production in Escherichia coli.", APPL ENVIRON MICROBIOL., vol. 73, no. 24, December 2007 (2007-12-01), pages 7814 - 7818, XP009120156
APPL.ENVIRON. BIOTECHNOL., vol. 73, no. 24, 2007, pages 7814 - 7818
APPL. MICROBIOL. BIOTECHNOL, vol. 77, no. 6, 2008, pages 1219 - 1224
LAUREN SALLUS JENKINS, JAURNAL OF BACETERIOLOGY, vol. 169, pages 42 - 52
SAMBROOK, J. ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
HASHIMOTO-GOTOH, T., GENE, vol. 241, 2000, pages 185 - 191
LAUREN SALLUS JENKINS, JOURNAL OFBACETERIOLOGY, vol. 169, pages 42 - 52
APPL.ENVIRON. BIOTECHNOL., vol. 73, no. 24, 2007, pages 7814 - 7818
APPL. MICROBIOL. BIOTECHNOL, vol. 77, no. 6, 2008, pages 1219 - 1224
LAUREN SALLUS JENKINS, JAURNAL OF BACETERIOLOGY, vol. 169, pages 42 - 52
SAMBROOK, J. ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
HASHIMOTO-GOTOH, T., GENE, vol. 241, 2000, pages 185 - 191
LAUREN SALLUS JENKINS, JOURNAL OFBACETERIOLOGY, vol. 169, pages 42 - 52
Attorney, Agent or Firm:
NAKAJIMA, Jun et al. (JP)
Nakajima 淳 (JP)
Nakajima 淳 (JP)
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