Title:
HIGHLY TOXIC AMYLOID OLIGOMER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/032821
Kind Code:
A1
Abstract:
Provided is a new and highly toxic amyloid oligomer Aβo*3F. The Aβo*3F is specifically bound by a 3F antibody, is the most important toxic ingredient in a mixture of Aβ oligomers, and has a strong pathogenic effect. Further provided is a binding agent that specifically binds to Aβo*3F, a composition containing Aβo*3F, and a use of Aβo*3F as a target in the prevention and/or treatment and/or diagnosis of MCI and/or AD in subjects.
Inventors:
LIU RUITIAN (CN)
HUANG YARU (CN)
XIE XIXIU (CN)
YU XIAOLIN (CN)
HUANG YARU (CN)
XIE XIXIU (CN)
YU XIAOLIN (CN)
Application Number:
PCT/CN2023/121346
Publication Date:
February 15, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
SHEN ZHEN WISDOM BIOPHARM CO LTD (CN)
International Classes:
A61K38/17; C07K14/47; A61K39/00; A61K39/395; A61P25/28; C07K1/02; C07K16/18
Foreign References:
| CN101463082A | 2009-06-24 | |||
| US20100143365A1 | 2010-06-10 | |||
| US20200289589A1 | 2020-09-17 | |||
| CN101802007A | 2010-08-11 | |||
| US20200181247A1 | 2020-06-11 |
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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