Title:
HISTONE H2A PEPTIDE DERIVATIVES AND ANALOGS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2005090387
Kind Code:
A3
Abstract:
Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury induced by noxious stimuli when administered to animals. Pharmaceutical compositions and methods of using these peptides are also disclosed. The pharmaceutical compositions according to the invention are useful for treating and protecting against inflammatory diseases, autoimmune diseases, for treating and protecting against tissue damage, and for inhibiting metalloproteinase activity, and for treating and protecting against diseases associated with the breakdown of extracellular matrix or connective tissues.
Inventors:
WORMSER URI (IL)
Application Number:
PCT/IL2005/000328
Publication Date:
February 02, 2006
Filing Date:
March 23, 2005
Export Citation:
Assignee:
UNIV JERUSALEM YISSUM RES DEV (IL)
WORMSER URI (IL)
WORMSER URI (IL)
International Classes:
C07K5/06; C07K5/065; C07K5/068; C07K5/083; C07K5/09; C07K5/093; C07K5/103; C07K5/107; C07K5/11; C07K5/113; C07K7/06; C07K14/47; (IPC1-7): C07K7/06; A61K38/08; A61P29/00; C12N5/10; C12N15/11; C12N15/63
Domestic Patent References:
| WO2003017920A2 | 2003-03-06 | |||
| WO1998009985A2 | 1998-03-12 |
Foreign References:
| EP1297753A1 | 2003-04-02 | |||
| EP0489577A1 | 1992-06-10 |
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