Title:
HIV-ENCODED CHEMOATTRACTANT
Document Type and Number:
WIPO Patent Application WO2000043037
Kind Code:
A3
Abstract:
The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various treatment modes for individuals infected with HIV. The invention further provides treatment modes for other localized diseases by controlling CD4+ cell trafficking and infiltration. In particular, the invention provides methodology for promoting CD4+ cell chemotaxis to a localized site of infection as a means of augmenting the efficacy of extant chemotherapeutic methods. The invention further provides methodology for diverting CD4+ cell infiltration from a localized site where the presence of CD4+ cells is detrimental to the clinical outcome, by providing a composition comprising Tat and Nef at a distinct site, such as blood, within the individual where the accumulation of CD4+ cells is less detrimental.
Inventors:
SOLL DAVID R (US)
SHUTT DAMON (US)
SHUTT DAMON (US)
Application Number:
PCT/US2000/001068
Publication Date:
November 30, 2000
Filing Date:
January 19, 2000
Export Citation:
Assignee:
UNIV IOWA RES FOUND (US)
SOLL DAVID R (US)
SHUTT DAMON (US)
SOLL DAVID R (US)
SHUTT DAMON (US)
International Classes:
A61K38/16; A61K38/20; A61K39/39; A61P31/18; C07K14/16; (IPC1-7): A61K38/16; A61K39/39; A61P29/00; A61P31/00; A61P31/18; A61P33/00
Domestic Patent References:
| WO1999027958A2 | 1999-06-10 |
Other References:
R. LAFRENIE ET AL.: "HIV 1 Tat protein promotes chemotaxis and invasive behaviour by monocytes", J. IMMUNOL., vol. 157, 1996, pages 974 - 977, XP000929467
A. ALBINI ET AL.: "HIV-1 Tat protein mimicry of chemokines", PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 13153 - 13158, XP002146039
D. SHUTT ET AL.: "HIV-induced T cell syncytia release a two-component T helper cell chemoattractant composed of Nef and Tat", J. CELL. SCI., vol. 112, 1999, pages 3931 - 3941, XP000938498
A. ALBINI ET AL.: "HIV-1 Tat protein mimicry of chemokines", PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 13153 - 13158, XP002146039
D. SHUTT ET AL.: "HIV-induced T cell syncytia release a two-component T helper cell chemoattractant composed of Nef and Tat", J. CELL. SCI., vol. 112, 1999, pages 3931 - 3941, XP000938498
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